Predictors of seizure outcome following cortical resection in pediatric and adolescent patients with medically refractory epilepsy |
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Authors: | Maha Gashlan Inge Loy-English Enrique C G Ventureyra D Keene |
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Institution: | (1) Division of Neurology, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada, CA;(2) Division of Neurosurgery, Department of Surgery, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada, CA |
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Abstract: | Several preoperative clinical variables have been reported to have value as predictors of seizure outcome following the surgical
resection of epileptogenic focus in adults who have had medically refractory epilepsy. The present paper reports the results
of a retrospective review of the ability of these variables to predict seizure outcome in a group of pediatric patients who
had medically refractory epilepsy and underwent surgical resection of an epileptogenic focus at the Children's Hospital of
Eastern Ontario. Variables in this review included age at first seizure, age at time of surgery, duration of seizures, seizure
type, sex, family history, etiology, level of intelligence, EEG data, results of imaging studies, findings on examination
of the central nervous system, and location and site of surgical resection. We found 64 patients who met the entry criteria
for this review. Normal intelligence and tumor as etiology were associated with a good postoperative seizure outcome in patients
who had a temporal resection; no variables had positive correlation with outcome in the extratemporal group. Caution must
be used in the extrapolation of data and inclusion of studies of predictors of seizure outcome for adults to pediatric age
groups.
Received: 8 June 1998 |
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Keywords: | Predictors Outcome Surgery Epilepsy Pediatrics |
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