早期血清中高敏C-反应蛋白含量水平对急性脑梗死预后的影响

目的探讨急性脑梗死（ACI）早期血清中高敏C-反应蛋白（HS-CRP）含量水平对ACI预后的影响。方法采用微粒化增强免疫固定试验测定265例ACI患者入院第2d血清中HS-CRP含量水平,另设30例健康人作对照。同时对入院时HS-CRP不同含量水平ACI患者入院后出血性转化（HT）及多脏器功能障碍综合征（MODS）发生率、病死率、生存者预后生活质量等进行分析。结果ACI组患者早期血清中HS-CRP含量水平明显高于对照组（P〈0.01）。本组共发生HT者31例,发生率为11.70%。且早期血清中HS-CRP含量水平越高HT发生率越高（P〈0.05）。死亡26例,病死率为9.81%。早期血清中HS-CRP含量水平越高ACI患者病死率越增加（P〈0.05）。发生MODS者28例,发生率为10.57%。HS-CRP含量水平越高ACI患者MODS发生率越高（P〈0.05）。早期血清中HS-CRP不同含量水平各组间生存者入院时NDS、ADL虽然存在差异,但各组间NDS、ADL比较差异不显著（P〉0.05）;其含量水平越高出院时NDS、ADL越降低（P〈0.05）。结论ACI组患者早期血清中HS-CRP含量水平明显升高,其含量水平越高HT及MODS发生率、病死率等升高或增加、且生存者预后生活质量越降低。

The influence of prognosis of different serum HS-CRP level on patients with acute cerebral infarction early

Objective To explore the influence of prognosis of different serum High sensitive C reactive protein（HS--CRP） HS--CRP level on patients with acute cerebral infarction （ACI） early. Methods With micronize strengthen immunofixation method, the serum HS--CRP level of 265 cases patients with ACI were measured on the second days after hospitalization. In addition,30 cases healthy volunteers were supposed as control group. Meanwhile, All cases patients with different serum HS--CRP level of complicating Hemorrhagic transformation （HT）, incidence rate of Multiple organ dysfunction syndrome （MODS） ,mortality and the quality of life of survivor prognosis were analyzed. Results The serum HS-- CRP level of patients with ACI were higher than control group （P 〈 0.01）, 31 cases patients were diagnosed as HT, and incidence was 11.70% （P 〈 0.01）. 26 cases were death at last, mortality were 9. 81% （P 〈 0.01）, 28 cases were diagnosed as MODS, incidence were 10.57% （P 〈 0.01）. All cases complicating HT, MODS and death at last were relational with serum HS- CRP level after hospitalized （P 〈 0.05）. The difference of Neurological deficiency score （NDS）, activity daily living （ADL） of patients with LCI were not significant on admission, and the difference was significant discharge （P 〉 0.05,P 〈 0.05）. Conclusions The serum HS--CRP level of patients with ACI are higher than normal,the level of patients is higher, the complicating HT, incidence rate of MODS, mortality is higher,The NDS and ADL are lower.