Synthesis of 4-hydroxycoumarin heteroarylhybrids as potential antimicrobial agents |
| |
Authors: | Siddiqui Zeba N N Mohammed Musthafa T Ahmad Anis Khan Asad U |
| |
Institution: | Department of Chemistry, Aligarh Muslim University, India. siddiqui_zeba@yahoo.co.in |
| |
Abstract: | A new series of 4-hydroxycoumarin derivatives 3a-d was synthesized by the reaction of 3-bromo-4-hydroxy coumarin 1 with various heteroaldehydes 2a-d in good yields. The synthesized compounds were characterized on the basis of their elemental and spectral (IR, (1)H-NMR and mass spectrometry) analysis. All target compounds were evaluated for their in-vitro antimicrobial activity against Streptococcus pyogenes, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli bacterial strains and fungal cultures of Candida albicans, Aspergillus fumigatus, Trichophyton mentagrophytes, and Penicillium marneffei by disk diffusion assay with slight modifications. The minimum inhibitory concentration (MIC) was determined for the test compounds as well as for reference standards. Among the tested compounds, 3a has shown the most potent antibacterial as well as antifungal activities. |
| |
Keywords: | Antibacterial activity Antifungal activity 3‐Bromo‐4‐hydroxycoumarin Dicoumarols Heteroaldehydes |
本文献已被 PubMed 等数据库收录! |
|