妊娠高血压综合征孕妇羊水儿茶酚胺水平与胎儿预后关系的研究

目的:探讨妊娠高血压综合征(妊高征,PIH)孕妇羊水中儿茶酚胺(CA)水平的变化。方法:采用高效液相(HPLC)方法对足月正常孕妇及妊高征孕妇羊水中去甲肾上腺素(NE)、肾上腺素(E)及多巴胺(DA)水平进行监测。选择对象均为择期剖宫产孕妇,正常对照组80例,妊高征组146例,其中轻度38例,中度44例,重度64例,并且对中重度妊高征孕妇存在胎儿合并症的羊水中CA进行分组测定,I组无合并症组,Ⅱ组合并胎儿宫内发育迟缓(IUGR),III组合并胎儿宫内窘迫,IV组IUGR合并胎儿宫内窘迫。结果:中重度妊高征孕妇羊水中NE、E及DA水平明显增加(P<0.05),以重度更为明显,合并IUCR或胎儿宫内窘迫者羊水中NE、E及DA水平明显高于对照组(P<0.05),无合并症组有增高趋势,但差异不显著。结论:妊高征孕妇羊水中CA水平与胎儿预后有关。

Study of the relationship between the catecholamine levels in maternal amniotic fluid in patients with pregnancy-induced hypertension and fetal intrauterine condition

Objective:To study amniotic fluid catecholamine(CA) levels in patients with pregnancy-induced hypertension(PIH).Methods:The levels of Noradrenaline(NE),Epinephrine(E) and Dopamine(DA) in amniotic fluid in the normal pregnant women and patients with PIH were monitored by high performance liquid chromatograpy(HPLC).All patients were selected cesarean section.There were 146 patients with PIH in this investigation,38 cases of them were mild PIH,44 cases of them were moderate and 64 cases of them were severe,and then collected 80 cases of the normal pregnant women as control group.According to fetal condition,all patients were divided into four groups:.group 1 without complications,group 2 intrauterine growth retardation(IUGR),group 3 fetal distress,group 4 IUGR and fetal distress.Results:The levels of NE,E and DA in moderate PIH were higher than that of control group,there were significant differences(P<0.05).however,the levels of NE,E and DA were more distinct increasing in patients with severe PIH.The levels of CA in Amniotic Fluid of patients with PIH whose fetus showed IUGR or fetal distress were higher than those of control group(P<0.05).Conclusion:The levels of CA in amniotic fluid of the patients with PIH relate to fetal prognosis.