高海拔地区急性脑梗死患者血清RBP水平与颈动脉斑块的关系

目的 探讨高海拔地区急性脑梗死(ACI)患者血清视黄醇结合蛋白(RBP)水平与颈动脉斑块的关系。方法 选择2016年12月-2017年12月在青海省人民医院住院治疗的135例ACI患者(ACI组)为研究对象,另选择98例健康者为对照(对照组); 通过采用颈动脉彩色超声检测斑块,免疫增强比浊法检测血清RBP水平,同时采用酶偶联测定法测定血清UA水平; 根据超声学检查,分为无斑块组(69例)、稳定斑块组(31例)、不稳定斑块组(35例),比较各组血清RBP水平。结果 ACI组血清RBP、UA水平显著高于对照组(P<0.05); 在ACI患者中不稳定斑块组血清RBP水平显著高于无斑块组和稳定斑块组(P<0.05); 通过Logistic回归分析显示血清RBP与发生颈动脉粥样斑块关系密切(OR=2.318,95% CI=0.007～0.721)。结论 高海拔地区ACI患者血清RBP水平很有可能成为预测颈动脉不稳定斑块的有效生物学标志物,并且可能与颈动脉斑块的稳定性有着密切的关系。

The relationship between serum level of retinol-binding protein and carotid plaques in patients with acute cerebral infarction at high altitude localities

ObjectiveTo investigate the relationship between the serum level of retinol-binding protein(RBP)and carotid plaques in patients with acute cerebral infarction(ACI)at high altitude localities.Methods 135 patients with acute cerebral infarction treated in our hospital were selected as the research object from December 2016 to December 2017. 98 healthy people were selected as healthy control group, namely ACI patients(ACI group)and 98 normal controls(control group). The plaque was detected by carotid artery color ultrasound, Serum RBP level was detected by immunoenhancement turbidimetry, and serum UA level was measured by enzyme linked coupling assay. the ACI patients were further divided into non-plaque subgroup(69 patients),stable carotid plaque subgroup(31 patients),and unstable carotid plaque subgroups(35 patients),the serum level of RBP was compared between the three groups.Results The serum levels of RBP and UA were significantly higher in the ACI group than those in the control group(P<0.05).In the ACI group, serum level of RBP were significantly higher in the unstable carotid plaque subgroup than that in the non-plaque subgroup and stable carotid plaque subgroup(P<0.05). The logistic regression analysis showed that RBP might be closely associated with the development of carotid plaque(odds ratio=2.318,95% confidence interval 0.007～0.721).Conclusion Serum RBP level might be an effective biomarker for predicting unstable carotid plaques, and might be closely associated with the stability of atherosclerotic plaques in patients with ACI at high altitude localities.