外周血中性粒细胞CD64及CRP在烧伤感染中的诊断价值探讨

目的分析探讨外周血中性粒细胞CD64及C反应蛋白(CRP)在烧伤感染中的诊断价值。方法选择2018年1月至2019年6月郑州大学第一附属医院烧伤科收治的92例烧伤患者作为研究对象,并按照感染程度将其分为脓毒症组(31例)、局部感染组(21例)和非感染组(40例),分别于治疗前和治疗第3、7天测定并对比外周血中性粒细胞CD64及CRP水平,绘制中性粒细胞CD64、CRP及两项指标联合检测对烧伤感染诊断价值的ROC曲线,分析其特异度和敏感度。结果治疗前3组患者中性粒细胞CD64及CRP水平对比,脓毒症组明显高于局部感染组与非感染组(P均<0.05),局部感染组明显高于非感染组(P<0.05);治疗第3、7天3组患者中性粒细胞CD64及CRP水平均呈现不同程度下降,但脓毒症组仍明显高于局部感染组与非感染组(P均<0.05),局部感染组仍明显高于非感染组(P<0.05)。ROC曲线分析结果显示:中性粒细胞CD64、CRP及两项指标联合检测的曲线下面积分别为0.719、0.655及0.872;两项指标联合检测的敏感度、特异度分别为88.46%、87.50%,明显高于中性粒...

The Diagnostic Value of Peripheral Blood Neutrophil CD64 and CRP in Burn Infection

Objective To analyze the diagnostic value of peripheral blood neutrophil CD64 and C-reactive protein (CRP) in burn infection. Methods 92 burn patients, admitted to the Department of Burns of the First Affiliated Hospital of Zhengzhou University from January 2018 to June 2019, were selected as research subjects and divided, according to the degree of infection, into sepsis group (31 cases), local infection group (21 cases) and non?infection group (40 cases). The levels of peripheral blood neutrophil CD64 and CRP were measured and compared before treatment and on the 3rd and 7th day of treatment, respectively. The ROC curves for predicting burn infection with neutrophils CD64, CRP and the combination of the two indicators were drawn, and their specificity and sensitivity were analyzed. Results The levels of neutrophil CD64 and CRP in the three groups were compared before treatment: their levels in the sepsis group were significantly higher than that in the local infection group and the non-infection group (all P < 0.05), and their levels in the local infection group was significantly higher than that in the non?infection group (P < 0.05); on day 3 and day 7 of treatment, the levels of neutrophil CD64 and CRP in the three groups showed different degrees of decrease: their levels in the sepsis group was still significantly higher than that in the local infection group and the non?infection group (all P < 0.05), and their levels in the local infection group was still significantly higher than that in the non-infected group (P < 0.05). ROC curve analysis showed that the areas under the curves of neutrophil CD64, CRP and the combination of the two indicators were 0.719, 0.655 and 0.872, respectively; the sensitivity and specificity of the detection with the combination of the two indicators were 88.46% and 87.50% , significantly higher than the sensitivity and specificity of neutrophil CD64-80.77% and 77.50% , and sensitivity and specificity of CRP-71.15% and 67.50% . Conclusion The levels of neutrophil CD64 and CRP are closely related to the degree of infection of burn patients. They have certain value in the early diagnosis of burn infection, and the detection with the combination of the two indicators has even higher diagnostic value.