Fcγ受体IIA基因多态性与慢性牙周炎易感性的相关性研究

目的　探讨Fcγ受体ⅡA基因多态性和慢性牙周炎的易感性相关关系。方法　采用序列特异性引物多聚酶链反应(PCR-SSP),对63例重度慢性牙周炎患者、103例轻中度慢性牙周炎患者及80名健康对照者的Fcγ受体 ⅡA基因多态性进行检测,比较各组间基因型分布及等位基因频率的差异。结果　FcγRⅡA-R/R131基因型在重度慢性牙周炎与健康对照组之间的分布差异有显著性(P<0·012 5),而在轻中度慢性牙周炎组与健康对照组、重度慢性牙周炎组与轻中度慢性牙周炎组之间的分布差异无显著性(P>0·012 5)。结论　FcγRⅡA-R/R131基因型与慢性牙周炎的严重程度相关,提示其可能与汉族人群慢性牙周炎的易感性有关。

The association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality]

OBJECTIVE: To investigate the association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality. METHODS: DNA samples were collected with buccal swabs from 63 patients with severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fc gamma receptor IIA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared. RESULTS: It was found that the frequency of Fc gamma RIIA-R/R131 genotype was significantly higher in patients with severe CP (19.05%) compared to that of the healthy controls (P < 0.0125). CONCLUSION: The Fc gamma RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.