膀胱癌CK20及Ki-67的表达及相关性

目的 探讨角蛋白20(CK20)和Ki-67在膀胱癌中的表达与膀胱癌的侵袭、转移及预后的关系.方法 用免疫组织化学SP法检测154例膀胱癌组织中CK20和Ki-67的表达.结果 CK20在103例肿瘤组织中有表达,阳性率为66.9%.CK20的表达和膀胱癌的T分期及远处转移呈正相关(P<0.05).Ki-67在126例肿瘤组织中有阳性表达,阳性率为81.8%.Ki-67在膀胱癌组织的表达与肿瘤病理分级、T分期、远处转移呈正相关(P<0.05).Spearman等级相关分析表明两者明显相关(P<0.05).结论 CK20及Ki-67可能参与了膀胱癌的侵袭与转移,CK20与Ki-67可作为预后判断因子,结合病理分级和临床分期分析能提高对膀胱癌患者预后判断的准确性.

The expression of CK20 and Ki-67 in bladder cancer

Objective To investigate the correlation of CK20 and Ki-67 expression in tumor to metastasis, invasion, and prognosis of bladder cancer. Methods The expression of CK20 and Ki-67 in 154 specimens of bladder cancer was detected by SP immunohistochemistry. Results Positive rate of CK20 was 66. 9% in bladder cancer tissues. CK20 staining in cancer tissue was positively related with T stage and distant metastasis (P<0.05). Positive rate of Ki-67 was 81.8% in bladder cancer tissues. Ki-67 staining in cancer tissue was positively related with pathologic grade and T stage and distant metastasis (P < 0.05). Spearman' s rank correlation had showed both correlations (P < 0. 05). Conclusion CK20 and Ki-67 maybe participate in invasion and metastasis of bladder cancer. CK20 and Ki-67 may be an prognostic factor and when used in combination with pathologic grading and clinical staging, may increase accuracy of predicting prognosis of patients with bladder cancer.