食管鳞癌遗传易感性与基质金属蛋白酶-1基因多态性的关系

目的 探讨基质金属蛋白酶-1(MMP-1)基因多态性与食管鳞癌发病风险的关系.方法 运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法检测450对病例与对照中MMP-1的1G/2G基因多态性.结果 与1G等位基因携带者(包括1G/1G及1G/2G基因型)比较,2G/2G基因型携带者与食管鳞癌显著相关[OR=1.39;95%可信区间(CI):1.06～1.81].此外,食管鳞癌的发病风险在吸炳者及女性中更加显著,其OR及95%CI分别为1.59(1.09～2.31)及1.76(1.05～2.97).结论 MMP-1基因多态性可能在食管鳞癌的发生过程中起到一定作用.

Polymorphism of the matrix metalloproteinase-1 and risk of esophageal squamous cell carcinoma

Objective Our study aimed to test the association between the matrix metalloproteinase-1 ( MMP-1) polymorphism and risk of esophageal squamous cell carcinoma ( ESCC ) . Methods We determined the MMP-1 polymorphism in 450 ESCC cases and 450 frequency-matched controls by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results We found evidence for a significant association between the 2G/2G genotype and ESCC risk compared with 1G allele,including 1G/1G genotype and 1G/2G genotype [OR = 1. 39;95% confidence interval (CI), 1. 06-1. 81].Furthermore,the increased risk was found to be in smokers (OR,1. 59;95% CI, 1. 09-2. 31) and in female (OR, 1.76;95% CI, 1.05-2. 97). Conclusion Our study suggests that the MMP-1 promoter polymorphism may play a role in the etiology of ESCC.