| 养肝熄风方药对帕金森病模型大鼠神经行为的影响 |
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| 引用本文： | 李文伟,蔡定芳,陈锡群,沈思钰.养肝熄风方药对帕金森病模型大鼠神经行为的影响[J].中国中西医结合杂志,2000,20(12):920-922. |
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| 作者姓名： | 李文伟 蔡定芳 陈锡群 沈思钰 |
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| 作者单位： | 上海医科大学华山医院!上海200040(李文伟，陈锡群，沈思钰)，山东省胜利油田中心医院!山东257034(蔡定芳) |
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| 基金项目： | 上海市卫生系统“百人计划”基金!(No .97BR0 1 6)，高等学校博士点专项科研基金!(No .9747)，卫生部科研基金!资助 (No .98- 2- 1 51 |
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| 摘 要： | 目的：探讨养肝熄风方药对帕金森病（Parkison′s disease,PD)模型大鼠神经行为的影响。方法：运用6-羟基多巴胺（6-OHDA）损毁大鼠中脑黑质致密部（SNc）和腹侧被盖区（VTA）两区多巴胺能神经元，造成PD模型；观察养肝熄风水煎醇提液对该模型阿朴吗啡（apomorphine）诱发旋转实验和阶梯实验的影响。结果：阿朴吗啡诱发旋转实验表明：养肝熄风方药可以降低PD大鼠阿朴吗啡诱发的旋转行为。阶梯实验表明：治疗前PD大鼠比对照组大鼠摄食的食物颗粒数明显减少。治疗后治疗组大鼠摄食的食物颗粒比模型组增多（P<0.05）。结论：养肝熄风方药能够改善PD大鼠的神经行为。
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| 关 键 词： | 帕金森病 神经行为学 养肝熄风方药 实验研究 |
Effects of yanggan xifeng recipe on changes of neurological behavior of rat of Parkinson's model] |
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| Authors: | LI Wenwei CAI Dingfang CHEN Xiqun |
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| Abstract: | OBJECTIVE: To investigate the effect of Yanggan Xifeng Recipe (YGXFR) for nourishing Liver to calm down endogenous Wind on neurological behavior of Parkinson's disease (PD) rat model. METHODS: PD rat model was established by destroying the substantia nigra condense area (SNc) and ventral tegmental area (VTA) unilaterally with 6-hydroxy dopamine (6-OHDA). The rats for control were injected in the same site with the same dose of normal saline. The animals were randomly divided into 3 groups (7 in each group), the control group, the model group and the TCM treated group. Staircase test and rotation test induced by apomorphine were performed in all groups and compared. RESULTS: The staircase test demonstrated that, after being treated with YGXFR, the food pellets intake were increased compared to model group (P < 0.05), and their rotation induced by apomorphine was lessened (P < 0.01). CONCLUSION: YGXFR could recover the neurological behavior deficits of PD rat models. |
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