| Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor β1 in vitro |
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| 引用本文： | 陈旭峰,郑树,高永良,戴惠芳,牟瀚舟,杨骅. Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor β1 in vitro[J]. 中华医学杂志(英文版), 1998, 0(6) |
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| 作者姓名： | 陈旭峰 郑树 高永良 戴惠芳 牟瀚舟 杨骅 |
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| 作者单位： | Chen Xufeng,Zheng Shu,Yang Hua(Cancer Research Institute, Zhejiang Medical University, Hangzhou 310006, China);Gao Yongliang,Dai Huifang,Mou Hanzhou(Zhejiang Cancer Research Institute, Hangzhou 310022, China) |
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| 摘 要： | ＧｒｏｗｔｈｒｅｇｕｌａｔｉｏｎｏｆｏｖａｒｉａｎｃａｎｃｅｒｃｅｌｌｉｎｅＨＯ８９１０ｂｙｔｒａｎｓｆｏｒｍｉｎｇｇｒｏｗｔｈｆａｃｔｏｒβ１ｉｎｖｉｔｒｏＣｈｅｎＸｕｆｅｎｇ陈旭峰，ＺｈｅｎｇＳｈｕ郑树，ＧａｏＹｏｎｇｌｉａｎｇ高永良，ＤａｉＨ...
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Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor β1 in vitro |
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| Chen Xufeng,Zheng Shu,Gao Yongliang,Dai Huifang,Mou Hanzhou,Yang Hua. Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor β1 in vitro[J]. Chinese medical journal, 1998, 0(6) |
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| Authors: | Chen Xufeng Zheng Shu Gao Yongliang Dai Huifang Mou Hanzhou Yang Hua |
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| Abstract: | Objective To further understand the role of growth regulation of human ovarian cancer cells by transforming growth factor (TGF) β1.Methods The cell proliferation, cAMP synthesis, gene expression, and induction of programmed cell death (PCD) in human epithelial ovarian cancer cell line HO-8910 cells exposed to TGFβ1 in vitro were studied.Results TGFβ1 inhibited cell growth and DNA synthesis, and induced G0/G1 arrest in cell cycle. It could also trigger PCD in cells. This induction of PCD may occur within G0/G1 phase. Meanwhile, the assay also showed that TGFβ1 could inhibit the mRNA expression of c-myc, EGFR and TGFβ1 genes in cells.Conclusions TGFβ1 can not only act as an autocrine to inhibit cell proliferation, but also trigger PCD in HO-8910 cells. These functions may be fulfilled through some specific signal transduction pathways. |
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