育龄妇女补充叶酸对预防神经管缺陷中的作用

目的分析叶酸在预防胚胎神经管畸形中的作用。方法选取有生育准备的育龄妇女并成功怀孕的孕妇1080例,将所有孕妇分成观察组和对照组,其中观察组780例,对照组300例,观察组在妊娠之前3个月与成功怀孕后的3个月内,每日服用叶酸0.4mg,对照组孕妇不服用任何叶酸片等,观察两组各自新生儿的先天性神经管缺陷的发生率。结果观察组孕妇在服用叶酸期间未曾有任何不良的药物反应与不良反应。观察组胎儿未出现神经管缺陷性疾病,而对照组有2例神经管缺陷,总发生率为0.67%。(P<0.05)。结论保证孕妇充分的叶酸补充能有效降低胎儿神经管畸形的发生率。因此,在准备怀孕初期到成功怀孕初的三个月内应该保证足够的叶酸补充,可以大大降低胎儿神经管缺陷性疾病。

Women of Childbearing Age Folic Acid Supplementation for the Prevention of Neural Tube Defects

Objective Analysis of folic acid in the prevention of the embryonic neural tube malformations in rats.Methods Choose fertility for women of childbearing age and pregnant women in 1080 cases,all pregnant women were divided into observation group and control group,including 780 cases in observation group,300 cases in the control group,the observation group in the three months before pregnancy and successful pregnancy after three months,the daily folic acid 0.4mg,control group women taking any folic acid tablets,observe two groups of the respective neonatal congenital neural tube defect occurrence rate.Results In the observation group of pregnant women taking folic acid period did not have any adverse drug reactions and side effects.Observation of fetal neural tube defects were not disease,while the control group with 2 cases of neural tube defects。