慢性排斥反应移植动脉硬化与增殖细胞核抗原表达

目的 探讨慢性排斥反应移植动脉硬化与增殖细胞核抗原（ＰＣＮＡ）表达的关系。方法 采用免疫组化ＳＰ法研究６１只大鼠的移植动脉，１０例慢性排斥反应移植肾动脉组织中的ＰＣＮＡ表达。结果 实验组：大鼠移植动脉中层ＰＣＮＡ术后７天达最高峰，内膜层术后２０天达最高峰，且细胞数明显增多，两者呈正相关。临床组：移植肾动脉ＰＣＮＡ最表达主要集中在内膜，其次为中层，外膜极少。结论 移植动脉硬化过程中细胞增殖与ＰＣＮＡ

Expression of PCNA in the transplant arteriosclerosis of chronic rejection

Objective To investigated the relationship between the expression of PCNA and transplant arteriosclerosis of chronic rejection. Methods The expression of PCNA in the allograft arteriosclerosis of 61 rats and the transplant renal artery in 10 patients of chronic rejection were studied with immunohistochemistry SP method. Results In the experiment group,the expression of PCNA in the media of transplant aorta showed a peak at 7 days postoperative,the intimal PCNA showed a peak at 20 days and the cell numbers increased.The expression of PCNA and the cell numbers showed a positive correlation.In the clinical group,the expression of PCNA was mainly found in the intimal membrane of transplant renal artery,the next was in the media,where as the exomembrane showed a few. Conclusions There was a close relationship between the increase of expression of PCNA and the cell proliferation.The expression of PCNA in the transplant artery of chronic rejection increased.It had significant relationship with the frequency or the degree of acute rejection.