Alpha globin gene number: population and restriction endonuclease studies |
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Authors: | Brittenham, G Lozoff, B Harris, JW Kan, YW Dozy, AM Nayudu, NV |
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Abstract: | Restriction endonuclease analysis was used to test a proposed genetic model using alpha-globin gene number to account for the observed distributions of the proportions of hemoglobin (Hb) S in sickle cell trait. In a subsample of specimens collected during a population survey in India, these studies confirmed that the postulated genotype was present in 22 of the 23 individuals examined. In the study population, the number of alpha-globin genes explains about 90% of the variance in the proportion of HbS in sickle cell trait (r2 = 0.895, p less than 10(- 10)). |
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