葛根素对血管性痴呆患者认知功能和事件相关电位P300的影响

目的观察葛根素对血管性痴呆（VaD）患者认知功能和听觉事件相关电位P300的影响。方法将70例VaD患者随机分成两组各35例，葛根素治疗组和对照组。应用简易精神状态检查量表（MMSE）评定两组患者治疗前后认知功能状况，并进行治疗前后P300检查。同时记录药物不良反应。结果两组各35例进入结果分析。治疗前两组MMSE评分、P300的潜伏期及波幅差异无显著性（均P〉0．05）。治疗14d、30d时，两组MMSE评分显著提高（均P〈0．01），P300潜伏期均有缩短，波幅均有提高（葛根素组P〈0．01，对照组P〈0．05）；治疗后14d时认知功能改善葛根素组明显优于对照组（总有效率分别为91．4％，71．4％）（P〈0．05）。两组治疗期间无严重不良反应。结论葛根素能够改善VaD患者的认知功能，这可能与葛根素的扩血管、脑保护作用有关。

Effects of kakkonein on cognitive,auditory event - related potentials P300 in patients with Vascular dementia

Objective To observe the effects of kakkonein on cognitive and auditory event - related potentials P300 in patients with Vascular dementia （VaD） o Methods 70 patients with VaD were randomly divided into two groups ： Kakkonein group （ n = 35 ）, treated with kakkonein injection; Control group （n = 35 ）, treated with basic medicine o Cognitive function and the amelioration of intelligence were assessed with mini mental state examination （MMSE）, and tBO0 was detected before and after treatmento The side effects of the drugs were recorded at the same timeo Results 35 cases in both groups were involved in the analysis of resultso There were no sigrtificant differences in the scores of MMSE,P300 lateneies and amplitudes from target before treatment between the two groups （all P 〉 0.05 ） o The scores of MMSE increased significantly （ all P 〈 0. 01 ） , P300 latencies reduced and amplitudes increased significantly（ kakkonein group P 〈 O. O1, control group P 〈 0. 05 ） in both two groupsl4 d and 30 d after treatment. The intellectual amelioration was significant in the kakkonein group than that of in the control group （91.4% ,71.4% ） （P 〈 0. 05 ） o No obvious adverse reaction was observed during treatment in both groupso Conclusions Kakkonein can improve the cognitive function in patients with VaD, It may be relate to cerebral protective effects and expanding cerebral vessels of kakkonein.