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Sex Differences and Laterality of Insulin Receptor Distribution in Developing Rat Hippocampus: an Immunohistochemical Study |
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| Authors: | Javad Hami Hamed Kheradmand Hossein Haghir |
| Affiliation: | 1. Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran 2. Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran 3. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran 4. Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | This study aimed to compare the regional distribution of insulin receptor in various portions of newborn rat hippocampus on postnatal days 0 (P0), 7 (P7), and 14 (P14) between male/female and right/left hippocampi. We found that the number of insulin receptor (InsR)-immunoreactive-positive (InsR+) cells in CA1 continued to increase until P7 and remained unchanged thereafter. A marked increase in distribution of InsR+ cells in CA3 from P0 to P14 was observed, although there was a significant decline in the number of InsR+ cells in dentate gyrus (DG) at the same time. No differences between the right/left and male/female hippocampi were detected at P0 (P?>?0.05). Seven-day-old female rats showed a higher number of labeled cells in the left than in the right hippocampus. Moreover, the differences between the number of InsR+ cells in area CA1 and CA3 were statistically significant between males and females (P?P? |
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