|
|||||
|
|
Urinary bacteria in adult women with urgency urinary incontinence |
|
| Authors: | Linda Brubaker Charles W. Nager Holly E. Richter Anthony Visco Ingrid Nygaard Matthew D. Barber Joseph Schaffer Susan Meikle Dennis Wallace Noriko Shibata Alan J. Wolfe |
| Affiliation: | 1. Departments of Obstetrics and Gynecology and Urology, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Avenue, Boulevard 120, Room 420, Maywood, IL, 60153, USA 2. Department of Reproductive Medicine, UC San Diego Health System, San Diego, San Diego, CA, USA 3. Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA 4. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA 5. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA 6. Obstetrics, Gynecology and Women’s Health Institute, Cleveland Clinic, Cleveland, OH, USA 7. Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA 8. Gynecologic Health and Disease Branch, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA 9. Health Sciences Division, Research Triangle Institute, Research Triangle Park, NC, USA 10. Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA |
| Abstract: | Introduction and hypothesisThis study’s aims were to detect and quantify bacterial DNA in the urine of randomized trial participants about to undergo treatment for urinary urgency incontinence (UUI) without clinical evidence of urinary tract infection (UTI) and to determine if the presence of bacterial DNA in baseline urine relates to either baseline urinary symptoms or UTI risk after urinary tract instrumentation.MethodsWomen without clinical evidence of baseline UTI were randomized to cystoscopic onabotulinum toxin A injection and oral placebo medication versus cystoscopic placebo injection and active oral medication. Bacterial DNA in participants’ catheterized urine was measured by quantitative polymerase chain reaction (qPCR).ResultsBacterial DNA was detected in the urine of 38.7 % of participants (60 out of 155). In these 60 qPCR-positive participants, baseline daily UUI episodes were greater than in the 95 qPCR-negative participants (5.71 [±2.60] vs 4.72 [±2.86], p?=?0.004). Neither symptom severity by questionnaire nor treatment outcome was associated with qPCR status or with qPCR level in qPCR-positive subjects. In contrast, the presence of urinary bacterial DNA was associated with UTI risk: only 10 % of the qPCR-positive women developed a UTI post-treatment, while 24 % of the qPCR-negative women did so. The median qPCR level for qPCR-positive samples did not differ significantly by UTI status (UTI 2.58?×?105 vs no UTI 1.35?×?105 copies/mL, p?=?0.6).ConclusionsThese results may indicate a urinary bacterial contribution to both baseline UUI and the risk of post-treatment UTI. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |