Interaction between glucose diet and ethanol on rat liver microsomal induction and liver plasma membrane damage in chronic hexachlorobenzene intoxication

Male Wistar rats fed for 60 days a glucose diet containing 17.5 mmol hexachlorobenzene/kg show a less pronounced increase in serum parameters and microsomal cytochrome P-450 concentration and a lower decrease in liver plasma membrane 5-nucleotidase, K⁺, Na⁺- and Mg⁺⁺-adenosine triphosphatase activities than the controls fed standard diet + hexachlorobenzene. Addition of 10% ethanol to the drinking water eliminates the glucose effect. The glucose diet and ethanol exert contrasting effects on microsomal enzyme induction and liver plasma membrane damage in hexachlorobenzene intoxication.Dedicated to Professor Dr. med. Herbert Remmer on the occasion of his 65th birthday