线粒体介导的细胞凋亡研究进展

细胞凋亡是生物体细胞受基因精确调控的主动消亡过程。多种分子参与、多重信号转导通路介导其调控机制，其中，线粒体介导的凋亡通路是重要的组成部分。凋亡信号可经有丝分裂原活化的蛋白激酶（MAPK）通路传递给线粒体，诱导细胞色素c释放，活化caspases蛋白酶家族、或诱导凋诱导因子（AIF）释放，执行凋亡。Bcl2家族成员参与凋亡调控，并作为桥梁沟通线粒体、死亡受体介导的通路间的对话。

Mitochondrion-mediated apoptosis

Apoptosis is programmed cell death regulated by genes. Different kinds of molecules and signal transduction pathways mediate apoptotic regulation mechanisms,in which mitochondrion play a key role. Apoptosis can be initiated by death signal which is transmitted to mitochondrion by mitogen activated protein kinase( MAPK) pathway, resulting in release of cytochrome c,activation of caspases family or release of apoptosis inducing factor(AIF).Moreover,Bcl2 family members take part in regulation of apoptosis and are involved in the crosstalk between mitochondrion and Fas/TNF receptor mediated pathway.