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NIDDM患者转铁蛋白尿和慢性并发症的关系
引用本文:徐一甄 史虹莉. NIDDM患者转铁蛋白尿和慢性并发症的关系[J]. 中华内分泌代谢杂志, 1997, 13(2): 101-103
作者姓名:徐一甄 史虹莉
作者单位:上海医科大学华山医院糖尿病研究室,上海第二医科大学科技中心实验室
摘    要:将70例NIDDM患者分成高转铁蛋白尿组和正常转铁蛋白尿组(每组35例),比较两组的并发症发生情况。结果:两组血糖控制情况基本相同;高转铁蛋白尿组年龄较大、病程较长、体重指数较大,血压较高、尿微量白蛋白排泄率明显增加,且与微量转铁蛋白尿指数呈正相关,心脏植物神经功能异常程度和眼底病变发生率也较严重,胰岛素浓度和Lp(a)水平也明显升高。提示转铁蛋白尿是糖尿病慢性并发症的信号。

关 键 词:NIDDM  转铁蛋白尿  慢性并发症

RELATIONSHIP BETWEEN TRANSFERRINURIA AND CHRONIC COMPLICATIONS IN PATIENTS WITH NIDDM
Xu Yizhen,Shi Hongli,Shen Zhizhou,et al.. RELATIONSHIP BETWEEN TRANSFERRINURIA AND CHRONIC COMPLICATIONS IN PATIENTS WITH NIDDM[J]. Chinese Journal of Endocrinology and Metabolism, 1997, 13(2): 101-103
Authors:Xu Yizhen  Shi Hongli  Shen Zhizhou  et al.
Affiliation:Xu Yizhen,Shi Hongli,Shen Zhizhou,et al.Research laboratory of diabetes,Hua Shan Hospital,Shanghai Medical University,Shanghai,200040
Abstract:According to the Transferrin/Creatinine (TRF/Cr)level, 70 NIDDM patients were divided into two groups, i.e., high TRF/Cr group and normal TRF/Cr group, 35 cases for each. Incidence of complications was compared between the two groups. The results showed that basically comparable control of blood sugar was reached in the two groups. It was found that the age of the patients, the course of diabetes, BMI and blood pressure were greater in high TRF/Cr group than those in normal TRF/Cr group. In high TRF/Cr group, there was an increase of urinary albumin excretion, and there was also a positive correlationship between urinary albumin excretion rate and transferrin excretion rate. Besides, the degree of cardiac autonomic neuropathy was severer, and the number of cases with diabetic retinopathy greater. Insulin and lipoprotein(a) levels were elevated as well. These results suggest that microtransferrinuria may be a signal of chronic complications of diabetes.
Keywords:NIDDM Microtransferrinuria Chronic complications
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