| 健康人口服克拉毒素颗粒剂的药代动力学 |
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| 引用本文： | 张伟,秦玉花,王斌.健康人口服克拉毒素颗粒剂的药代动力学[J].中国药房,1999(5). |
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| 作者姓名： | 张伟 秦玉花 王斌 |
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| 作者单位： | 河南省人民医院!郑州市，450003，河南省人民医院!郑州市，450003，河南省人民医院!郑州市，450003 |
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| 摘 要： | 目的：研究克拉霉素颗粒剂在健康人体内的药代动力学。方法：10名健康志愿者，单剂量口服克拉霉素片500mg，经时采集静脉血HPLC法测定血药浓度，药-时数据用3p87程序处理。结果：克拉霉素颗粒剂的药动学参数分别为：Tmax（1．89±0．60）h，Cmax（2.30±0.43）μg/ml，T1/2K（2．85±0.57）h，lagtime（0.06±0.03）h，V／F（139.8±40.3）L，AUC（16.61±2．80）μg／（h·ml）。结论：口服同剂量克拉霉素的药动学参数值与国外文献有明显的差异。
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| 关 键 词： | 克拉霉素 颗粒剂 药动学 HPLC |
Studies on Pharmacokinetics of Clarithromycin Granules in Healthy Volunteers |
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| ZHANG Wei, QIN Yuhua,WANG Bin.Studies on Pharmacokinetics of Clarithromycin Granules in Healthy Volunteers[J].China Pharmacy,1999(5). |
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| Authors: | ZHANG Wei QIN Yuhua WANG Bin |
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| Abstract: | OBJECTIVE: To study the pharmacokinetics of clarithromycin granules in healthy volunteers. METHODS: Asingle dose of 500mg clarithromycin granules was given to 10 healthy volunteers separately, the blood samples were collected atgiven times and the blood drug concentrations were detected with HPLC. The concentration--time data were processed with 3p87program. RESULTS: The results of pharmacokinetic parameters of clarithromycin granules were as follows: Tmax(1. 89 ± 0. 60)h, Cmax(2. 30 ± 0. 43) μg/ ml, T1/2k(2. 85 ± 0. 57) h, lag time (0. 06 ± 0. 03) h, V/ F (139. 8 ± 40. 3) L, AUC (16. 61 ± 2. 80) μg/(h' ml). CONCLUSION: The pharmacokinetic parameters of clarithromycin obtained here are different from those reported inwestern countrIes. |
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| Keywords: | clarithromycin granule pharmacokinetics HPLC |
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