MRI及31P-MRS在脂质沉积性肌病中的诊断

目的:应用磁共振成像(MRI)及磷频谱(31P-MRS)评价脂质沉积性肌病(LSM)的影像表现,探讨其临床应用价值.方法:对经病理证实的6例LSM和17例健康对照者进行MRI及31P-MRS检查.结果:6例LSM患者大腿后组肌群和内侧肌群T1 WI及T2 WI上均表现为多发小斑点状高信号,T2 WI抑脂后信号减低;LSM组PCr(磷酸肌酸)、PCr/ATP(三磷酸腺苷)和磷酸化能力(PP)较对照组明显降低(P＜0.05),二磷酸腺苷(ADP)、Pi(无机磷)、Pi/ATP、Pi/PCr较对照组明显增高(P＜0.05),PH与对照组无明显差别(P=0.6395).结论:MRI联合31P-MRS检查有利于LSM的诊断、鉴别诊断.

Application of MRI and 31P-MRS in Lipid Storage Myopath

Objection:To investigate the MRI and 31P-MRS features of lipid storage myopathy (LSM),and evaluate their clinical application values.Methods:6 cases of LSM confirmed by pathologic biopsy and 17 normal volunteers as control were performed MRI and 31P-MRS examinations. Results:Posterior muscle group and medialis muscle group displayed hyperintensity on T1WI and T2WI in all patients,and attenuated signal intensity on T2WI with fat saturation.Compared with the control group,PCr,PCr/ATP and phosphorylation potential (PP) of the LSM group obviously decreased (P<0.05),but ADP,Pi,Pi/ATP,Pi/PCr markedly increased (P<0.05),PH has no significant difference between LSM and control group.Conclusion:MRI with 31P-MRS can be helpful to the diagnosis and differential diagnosis of LSM.