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Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk
Authors:V. Parikka  K. N?nt?-Salonen  M. Saarinen  T. Simell  J. Ilonen  H. Hy?ty  R. Veijola  M. Knip  O. Simell
Affiliation:(1) Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, PO Box 52, 20521 Turku, Finland;(2) Department of Pediatrics, University of Turku, Turku, Finland;(3) Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland;(4) Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland;(5) Immunogenetics Laboratory, University of Turku, Turku, Finland;(6) Department of Virology, University of Tampere, Tampere, Finland;(7) Department of Clinical Microbiology, Centre of Laboratory Medicine, Tampere University Hospital, Tampere, Finland;(8) Department of Pediatrics, Oulu University Hospital, Oulu, Finland;(9) Department of Pediatrics, University of Oulu, Oulu, Finland;(10) Children’s Hospital, Helsinki University Central Hospital, Helsinki, Finland;(11) Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland;(12) Folkh?lsan Research Center, Helsinki, Finland;(13) Department of Pediatrics, Tampere University Hospital, Tampere, Finland
Abstract:

Aims/hypothesis  

The aim of the study was to investigate the timing of the appearance of autoantibodies associated with type 1 diabetes between birth and puberty, the natural fate of these autoantibodies and the predictive power of autoantibody concentrations for early progression to clinical diabetes.
Keywords:
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