Renal scarring sequelae in childhood Kawasaki disease |
| |
Authors: | Jieh-Neng Wang Yuan-Yow Chiou Nan-Tsing Chiu Mei-Ju Chen Bi-Fang Lee Jing-Ming Wu |
| |
Institution: | (1) Institute of Clinical Medicine, National Cheng Kung University Medical College, Tainan, 70421, Taiwan;(2) Department of Pediatrics, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan, 70428, Taiwan;(3) Department of Nuclear Medicine, National Cheng Kung University Hospital, Tainan, 70428, Taiwan;(4) Department of Nursing, Chung Hwa Institute of Technology, Tainan, 71703, Taiwan |
| |
Abstract: | To assess renal inflammation and its sequelae in Kawasaki disease (KD) patients, we conducted a prospective study in a university
medical center setting in Taiwan. From June 2002 to January 2005, 50 children with KD were enrolled, and after admission,
all received technetium-99m dimercaptosuccinic acid scintigraphy single photon emission computed tomography (DMSA renal SPECT),
the results of which were used as the reference standard for determining renal inflammation. Patients with renal inflammation
underwent another DMSA renal SPECT more than 6 months later to evaluate the sequelae. We found that 26 of the 50 patients
(52%) had renal inflammatory foci. There were no significant relationships between clinical or laboratory parameters and renal
involvement in KD, except the presence of coronary artery lesions P < 0.01; odds ratio (OR) 5.18; 95% confidence interval (CI) 1.52–17.65]. Although all patients were free of clinical symptoms,
the 6-month follow-up DMSA renal SPECT showed renal scarring in 11 of the 24 patients (46%). Patients with an initial abnormal
renal ultrasound did predict a greatly increased risk of scarring (P < 0.05; OR 16.2; 95% CI 1.27–206.20). In conclusion, this study demonstrated that the potential long-term clinical impact
of KD is not limited to coronary artery lesion sequelae but also includes renal scar formation.
Financial support: Grants from the National Cheng Kung University Medical Center. |
| |
Keywords: | Kawasaki disease Vasculitis Renal inflammation Renal scarring DMSA renal SPECT |
本文献已被 PubMed SpringerLink 等数据库收录! |
|