联检脑脊液中LAM-IgG和TB-DNA在诊断结核性脑膜炎中的应用

目的　了解脑脊液 (CSF)中阿拉伯糖甘露糖脂IgG抗体 (LAM-IgG)和TB-DNA指标对结脑的诊断价值。方法 以CSF为标本，用酶联免疫吸附试验 (ELISA)检测LAM-IgG，用聚合酶链反应(PCR)检测TB-DNA。结果 102份结脑病人CSF标本，LAM-IgG阳性率51.0% (52102)，TB-DNA阳性率81.4% (83102)，LAM-IgG阳性及 或TB-DNA阳性共93例 (91.2%)。40份非结核性的中枢神经系统疾病病例的CSF标本，均未检出LAM-IgG和TB-DNA.结论 LAM-IgG和TB-DNA均是诊断结脑的较好的指标，两者联检可进一步提高检测敏感性。

Uniting detection of lipoarabinomannan-IgG and TB-DNA in cerebrospinal fluid for the diagnosis of tuberculous meningitis

Objective To understand the value of lipoarabinomannan IgG and TB DNA in cerebrospinal fluid (CSF) in the diagnosis of tuberculous meningitis.Methods CSF was the detective specimen.LAM IgG was detected with enzyme linked immunosorbent assay (ELISA).TB DNA was detected with polymerase chain reaction (PCR).Results The positive rate of LAM IgG and TB DNA in 102 patients with tuberculous meningitis was 51.0%(52/102) and 81.4%(83/102).The positive rate of LAM IgG and TB DNA was 91.2%(93/102).But 40 control cases were all negative.Conclusion LAM IgG and TB DNA in CSF were useful index for the diagnosis of tuberculous meningitis.