| 碱性成纤维细胞生长因子在肾癌中的表达及意义 |
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| 引用本文： | 车乐,朱积川,姜辉,李鹰,王晓峰,侯树坤. 碱性成纤维细胞生长因子在肾癌中的表达及意义[J]. 临床泌尿外科杂志, 2001, 16(8): 364-365 |
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| 作者姓名： | 车乐 朱积川 姜辉 李鹰 王晓峰 侯树坤 |
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| 作者单位： | 1. 北京军区总医院泌尿外科
2. 北京医科大学人民医院泌尿外科 |
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| 摘 要： | 目的：探讨碱性成纤维细胞生长因子（b-FGF)在肾癌中的表达及意义。方法：采用斑点杂交技术测定20例肾癌患者癌组织，癌旁和周围正常肾组织中b-FGF mRNA的表达情况。结果：肾癌组织中b-FGF mRNA明显高于癌旁和周围正常肾组织（P＜0．01）,b-FGF mRNA的升高与肿瘤分期和分级密切相关，与肿瘤大小无明显关系。结论：b-FGF在肾癌组织中自身分泌，与肾癌的发生和发展密切相关。
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| 关 键 词： | 肾肿瘤 碱性成纤维细胞生长因子 斑点杂交技术 |
| 文章编号： | 1001-1420(2001)08-0364-02 |
| 修稿时间： | 2000-08-28 |
Expression of bFGF in renal cell carcinoma |
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| CHE Le ZHU Jichua JIANG Hui LI Ying WANG Xiaofeng HOU Shukun. Expression of bFGF in renal cell carcinoma[J]. Journal of Clinical Urology, 2001, 16(8): 364-365 |
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| Authors: | CHE Le ZHU Jichua JIANG Hui LI Ying WANG Xiaofeng HOU Shukun |
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| Affiliation: | CHE Le 1 ZHU Jichua 2 JIANG Hui 2 LI Ying 2 WANG Xiaofeng 2 HOU Shukun 2 |
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| Abstract: | Purpose:To investigate the clinical significance of bFGF in human renal carcinoma.Methods:20 cases of renal carcinoma were examined using RNA dot blot hybridization.Results:bFGF expression was significantly higher in human renal cancer tissue than the normal human renal tissue and tissue surrounding the tumor. bFGF expression was of no statistic significance as to tumor size, but it was of statistic significance as to clinical stage or clinical grade.Conclusions:bFGF is secreted by tumor tissue itself. bFGF is closely involved in the development and growth of renal cell. |
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| Keywords: | Tumor of kidney Basic fibroblast growth factor Dot blot hybridization |
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