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| 血管紧张素转换酶基因缺失纯合型与糖尿病肾病相关联 | |
| 引用本文： | 陈素杰,周哲,陈孟芝,徐茜,董瑞琴,杨晓娟,邱长春. 血管紧张素转换酶基因缺失纯合型与糖尿病肾病相关联[J]. 基础医学与临床, 2000, 20(5): 27-29 |
| 作者姓名： | 陈素杰 周哲 陈孟芝 徐茜 董瑞琴 杨晓娟 邱长春 |
| 作者单位： | 1. 辽宁省抚顺市中心医院,辽宁,113006 2. 四川省广汉市人民医院,四川,618300 3. 河北省唐山市工人医院,河北,063000 4. 中国医学科学院基础医学研究所,中国协和医科大学,基础医学院,分子生物学室,北京,100005 |
| 基金项目： | 国家自然科学基金!39670693 39870687 |
| 摘 要： | 应用ＰＣＲ扩增方法检测２０３例ＮＩＤＤＭ患者和１６５例正常对照者血管紧张素（ＡＣＥ）基因的１６内含子中２８７ｂｐ片段缺失／插入多态性。结果显示，糖尿病肾病患者组ＡＣＥ基因缺失纯合型（ＤＤ）频率明显高于非肾病组和正常对照组，Ｐ〈０．００１；ＤＤ缺失纯合型患者肾病进展速度明显快于缺失／插入（ＤＩ）杂合型及插入／插入（ＩＩ）纯合型糖尿病患者，Ｐ〈０．０１。表明ＡＣＥ基因缺失纯合型是糖尿病肾病的独立危险因 |
| 关 键 词： | 血管紧张素转换酶 基因多态性 糖尿病肾病 |
| 修稿时间： | 2000=04-12 |
Association of DD genotype of ACE gene with diabetic nephropathy |
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| CHEN Shu-je ZHOU Zhe CHEN Mong-zhi et al Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing China. Association of DD genotype of ACE gene with diabetic nephropathy[J]. Basic Medical Sciences and Clinics, 2000, 20(5): 27-29 | |
| Authors: | CHEN Shu-je ZHOU Zhe CHEN Mong-zhi et al Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing China |
| Affiliation: | CHEN Shu-je ZHOU Zhe CHEN Mong-zhi et al Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 China |
| Abstract: | To investigate the association of deletion/insertion polymorphism the onset and of angiotensin converting enzyme ACE gene with diabetic nephropathy in NIDDM A case-control study was carried out in 203 NIDDM patients 109 with DN 94 without DN and 216 control subjects The 287bp deletion/insertion polymorphism of ACE gene was deleted by polymerase chain reaction PCR DD genotype frequencies were significantly increased in DN group than that in the group without DN and controls DN v.s control P<0.001 DN v.s NDN P<0.01 respectivity conclusion the DD genotype of ACE gene might be an independent risk factor for the onset and procession of diabetic nephropathy in chinese Han's NIDDM patients |
| Keywords: | Angiotensin converting enzyme gene polymorphism diabetic nephropathy |
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