| 单核细胞趋化蛋白-1在口腔鳞癌中的表达及意义 |
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| 引用本文： | 杨建斌,冯红超,宋宇峰.单核细胞趋化蛋白-1在口腔鳞癌中的表达及意义[J].贵阳医学院学报,2005,30(2):111-113. |
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| 作者姓名： | 杨建斌 冯红超 宋宇峰 |
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| 作者单位： | 贵阳医学院附院,口腔科,贵州,贵阳,550004 |
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| 基金项目： | 贵州省第二批跨世纪人才省政府专项基金——黔科合人专字(2000)9813号 |
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| 摘 要： | 目的:探讨单核细胞趋化蛋白-1(monoeyte chemoattractant protein-1,MCP-1)在口腔鳞癌组织中的表达及其临床意义.方法:应用免疫组织化学SABC法检测41例口腔鳞癌组织中MCP-1的表达,并以10例正常口腔黏膜组织作为对照.结果:口腔鳞癌组织中MCP-1的表达较正常组织增加,差异有统计学意义;口腔鳞癌中MCP-1阳性表达主要分布在癌细胞和巨噬细胞的胞浆中,MCP-1的表达与肿瘤细胞的分化和转移有关.结论:MCP-1可能参与了口腔鳞癌的发展和转移.
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| 关 键 词： | 单核细胞趋化蛋白-1 表达及 免疫组织化学SABC法 口腔鳞癌组织 MCP-1 口腔黏膜组织 临床意义 正常组织 巨噬细胞 阳性表达 肿瘤细胞 统计学 癌细胞 转移 |
| 文章编号： | 1000-2707(2005)02-0111-03 |
| 修稿时间： | 2004年12月17 |
The Expression of Monocyte Chemoattractant Protein-1 and Its Clinical Significance In Human Oral Squamous Cell Cancer |
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| YANG Jian-bin,FENG Hong-chao,SONG Yu-feng.The Expression of Monocyte Chemoattractant Protein-1 and Its Clinical Significance In Human Oral Squamous Cell Cancer[J].Journal of Guiyang Medical College,2005,30(2):111-113. |
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| Authors: | YANG Jian-bin FENG Hong-chao SONG Yu-feng |
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| Abstract: | Objective: To study the expression of monocyte chemoattractant protein-1 (MCP-1)in the tissue of oral squamous cell cancer (OSCC) and its clinical significance. Methods: The expression of MCP-1 in 41 cases of OSCC and 10 specimens of normal oral epithelial tissue was assessed with SABC immunohistochemical method. Results: The expression of MCP-1 was higher in OSCC than in normal oral mucous tissue. There was a relation between the expression of MCP-1 and tumor differentiation and lymphatic metastasis. Conclusion: MCP-1 might participate the progress and lymphatic metastasis of human OSCC. |
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| Keywords: | carcinoma squamous cell mouth monocyte chemoattractant protein-1 immunohistochemistry |
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