| 子宫内膜癌中E2F-1和p-p38的表达及意义 |
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| 引用本文： | 周海霞,时志民,王蕾,司军英,吴彩花. 子宫内膜癌中E2F-1和p-p38的表达及意义[J]. 现代中西医结合杂志, 2013, 0(2): 123-124,130 |
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| 作者姓名： | 周海霞 时志民 王蕾 司军英 吴彩花 |
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| 作者单位： | 河北省邯郸市中西医结合医院;河北工程大学医学院;河北省邯郸市中心医院;河北省邯郸市传染病医院 |
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| 摘 要： | 目的检测子宫内膜癌组织中E2F-1和p-p38表达情况并探讨其意义。方法采用免疫组织化学S-P法检测60例子宫内膜癌、32例正常子宫内膜组织中E2F-1和p-p38的表达情况。结果子宫内膜癌组织中E2F-1和p-p38表达定位于细胞核,其阳性表达率分别为58%(35/60)和55%(33/60);而正常子宫内膜组织均无表达。两者的表达与肌层浸润程度、淋巴结转移、临床分期及病理分期有关;在子宫内膜癌组织中E2F-1和p-p38两者之间比较表达呈正相关(P<0.05)。结论 E2F-1和p-p38在子宫内膜癌中呈高表达,且与子宫内膜癌的发生、发展和转移密切相关。
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| 关 键 词： | 子宫内膜癌 E2F-1 p-p38 免疫组化 |
Expression and significance of E2F-1 and p-p38 in endometrial carcinoma |
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| Zhou Haixia,Shi Zhimin,Wang Lei,Si Junying,Wu Caihua. Expression and significance of E2F-1 and p-p38 in endometrial carcinoma[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2013, 0(2): 123-124,130 |
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| Authors: | Zhou Haixia Shi Zhimin Wang Lei Si Junying Wu Caihua |
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| Affiliation: | 1.Handan Hospital of Integrated Traditional and Western Medicine,Handan 056002,Hebei,China;2.Medical College of Hebei University of Engineering,Handan 056001,Hebei,China;3.Handan Central Hospital,Handan 056001,Hebei,China;4.Handan Hospital for Infectious Diseases,Handan 056002,Hebei,China) |
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| Abstract: | Objective It is to determine the expression of E2F-1 and p-p38 in the endometrial carcinoma and to explore the significance.Methods The expressions of E2F-1 and p-p38 in 60 cases of endometrial cancer and 32 cases of normal endometrial tissue by immunohistochemistry S-P method.Results The expressions of E2F-1 and p-p38 were located with the cytoplasm and the endometrial,and their positive expression rates were 58%(35/60) and 55%(33/60) respectively which were significantly higher than that in normal endometrial tissue.All of their expressions were related with myometrial invasion,lymph nodemetastasis,clinical stage and pathological staging(P<0.05).In endometrial carcinoma,the expressions of E2F-1 and p-p38 were positively correlated with each other(P<0.05).Conclusion E2F-1 and p-p38 were highly expressed in the endometrial cancinoma and their expressions were related with the development and metastasis of endometrial carcinoma. |
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| Keywords: | endometrial carcinoma E2F-1 p-p38 immunohistochemistry |
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