| Ezrin、E-cadherin在食管鳞癌中的表达及临床意义 |
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| 引用本文： | 翟建文,杨晓刚,杨福申,胡基刚,华文霞.Ezrin、E-cadherin在食管鳞癌中的表达及临床意义[J].癌症,2010,29(3):343-347. |
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| 作者姓名： | 翟建文 杨晓刚 杨福申 胡基刚 华文霞 |
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| 作者单位： | 河北工程大学附属医院胸外科; |
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| 基金项目： | 河北省科技厅支撑计划项目(编号:0720611027D)~~ |
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| 摘 要： | 背景与目的:有研究表明膜细胞骨架组织连接蛋白埃兹蛋白(Ezrin)能够促进肿瘤转移,可与上皮钙黏素相互作用,参与肿瘤细胞的转移过程。本研究探讨Ezrin和E-cadherin在食管鳞状细胞癌中的表达及与临床病理因素之间的关系,分析其在食管鳞癌中的诊断价值。方法:应用组织芯片技术免疫组织化学法(SP法)检测76例食管鳞状细胞癌患者组织标本及癌旁正常鳞状上皮中Ezrin和E-cadherin的表达情况,结合临床相关因素进行卡方检验及非参数检验等统计学分析。结果:76例食管癌旁正常鳞状上皮中Ezrin阳性35例(46.1%),E-cadherin阳性74例(97.4%);76例食管鳞癌组织中Ezrin阳性63例(82.9%),E-cadherin阳性34例(44.7%)。Ezrin表达与食管鳞癌的浸润深度和淋巴结转移显著相关(P<0.05);E-cadherin与肿瘤分化程度和淋巴结转移显著相关(P<0.05),随肿瘤分化程度的降低,E-cadherin的表达缺失率逐渐增加。Ezrin表达升高和E-cadherin的表达缺失呈负相关。结论:Ezrin和E-cadherin均与食管鳞癌的发生、转移有关,且两者表达呈负...
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| 关 键 词： | 食管鳞癌 Ezrin E-cadherin 组织芯片 免疫组化 |
Expression and clinical significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma |
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| Jian-Wen Zhai,Xiao-Gang Yang,Fu-Shen Yang,Ji-Gang Hu,Wen-Xia Hua.Expression and clinical significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma[J].Chinese Journal of Cancer,2010,29(3):343-347. |
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| Authors: | Jian-Wen Zhai Xiao-Gang Yang Fu-Shen Yang Ji-Gang Hu Wen-Xia Hua |
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| Institution: | Jian-Wen Zhai,Xiao-Gang Yang,Fu-Shen Yang,Ji-Gang Hu,Wen-Xia Hua Department Cardiothoracic Surgery,The Affiliated Hospital of Hebei University of Engineering,H,an,Hebei 056002,P.R. China |
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| Abstract: | Background and Objective: It has been proven that Ezrin protein may interact with E-cadherin protein and take part in metastasis of tumor cells. This study was to investigate the expressions of Ezrin and E-cadherin in esophageal squamous cell carcinoma (ESCC) and their relationship with the clinicopathologic factors,and to analyze their diagnostic values for ESCC. Method: The expression of Ezrin and E-cadherin in 72 specimen of ESCC and the para-cancer normal squamous epithelium was detected using tissue ar... |
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| Keywords: | Esophageal neoplasm Ezrin E-cadherin tissue array immunohistochemistry |
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