首页 | 本学科首页   官方微博 | 高级检索  
     

大鼠严重烧伤早期胃酸分泌功能改变的机制及其在急性胃粘损 …
引用本文:朱立 陈德昌. 大鼠严重烧伤早期胃酸分泌功能改变的机制及其在急性胃粘损 …[J]. 中华普通外科杂志, 2000, 15(2): 88-90
作者姓名:朱立 陈德昌
作者单位:[1]中国人民解放军第三军医大学西南医院烧伤研究所 [2]中国医学科学院北京协和医院加强医疗科
摘    要:目的 研究严重烧伤早期胃酸分泌功能改变及其发性机制,探讨其在急性胃粘膜损害防治中的意义。方法 采用Wistar大鼠制作30%体表(total body surface area,TBSA)三度烧伤模型,对烧伤早期胃酸分泌功能、胃粘膜血流量和胃粘膜能荷进行动态观察。结果 烧伤后3h胃液量、胃液总酸度和总酸排出量均已显著低于对照组(P〈0.01),伤后6h上述观察指标值继续下降,并于烧伤后12h降至最

关 键 词:烧伤 胃粘膜 能量代谢 胃酸 大鼠
修稿时间:1998-05-26

Changes of gastricacid production in early postburn period and their relevance to the prevention andtreatment of acute gastric mucosal lesions
ZHU Li,YANG Zongcheng,LI Ao,et al.. Changes of gastricacid production in early postburn period and their relevance to the prevention andtreatment of acute gastric mucosal lesions[J]. Chinese Journal of General Surgery, 2000, 15(2): 88-90
Authors:ZHU Li  YANG Zongcheng  LI Ao  et al.
Affiliation:ZHU Li,YANG Zongcheng,LI Ao,et al. Burn Research Institute,Southwest Hospital,Third Millitary Medical University,Chongqing 400038,China
Abstract:Objectives To investigate the changes of gastric acid production and their mechanisms in early postburn period in rats. Methods A rat model with 30% of total body surface area (TBSA) full thickness burn injury was used and the gastric acid production, together with gastric mucosal blood flow (GMBF) and energy charge (EC) were dynamically monitored within 48 hr postburn. Results At 3 hr postburn, all the gastric juice volume, total acidity and acid output had already significantly decreased, which sustained and reached the lowest level at 12 hr postburn; although restored to some extent at 24 hr postburn,all parameters were still statistically lower than that of control animals. The GMBF and EC were also significantly reduced after severe burns, which was consistent with the trend of gastric acid production changes. Conclusions Gastric acid production, as well as GMBF and EC were predominantly decreased in the early postburn stage. The results suggested that gastric mucosal ischemia and hypoxia with resultant disturbance in energy metabolism, but not gastric acid might be the decisive factor in the pathogenesis of AGML after thermal injury, and that the preventive use of anti and neutralizing acid drugs in early postburn burn period was unreasonable in some respects. Therefore, taking effective measures to improve gastricmucosal blood perfusion as early as possible postburn might be the preferable way for the AGML prevention and treatment.
Keywords:Burns  Gastric mucosa  Gastric acid  Energy metabolism
本文献已被 CNKI 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号