High-dose selenium substitution in sepsis: a prospective randomized clinical trial |
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| Authors: | Jiri Valenta Helena Brodska Tomas Drabek Jan Hendl Antonin Kazda |
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| Affiliation: | (1) Department of Anaesthesiology, Resuscitation and Intensive Care, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 128 08 Prague 2, Czech Republic;(2) Institute of Clinical Biochemistry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic;(3) Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;(4) Department of Kinanthropology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic |
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| Abstract: | Objective Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality. |
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