Solubilization of rapamycin |
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Authors: | Simamora P Alvarez J M Yalkowsky S H |
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Institution: | Pharmaceutical Research and Development, Schering-Plough HealthCare Products, Inc., 3030 Jackson Avenue, Memphis, TN 38151, USA. pahala.simamora@spcorp.com |
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Abstract: | The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (>1000-fold) increase in the aqueous solubility of rapamycin. |
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