葛根素治疗急性脑梗死42例

目的：观察葛根素对急性脑梗死患者血液流变学和纤维蛋白单体聚合功能的影响。方法：急性脑梗死患者84例，随机分为治疗组和对照组各42例。对照组采用脱水、护脑、改善微循环治疗，治疗组在对照组用药的基础上联合应用葛根素250 mL(600 mg)静脉滴注，qd，10 d为1个疗程，治疗前和治疗第10天进行血液流变学和纤维蛋白单体聚合功能的检测。结果：治疗组和对照组总有效率分别为95.23%，76.19%，差异有显著性(P＜0.05)。治疗组治疗前后血液流变学和纤维蛋白单体聚合功能显著改善。结论：葛根素可通过改善血液流变学和纤维蛋白单体聚合功能发挥治疗急性脑梗死的作用。

Puerarin in the Treatment of 42 Cases of Acute Cerebral Infarction

Objective:To survey the effect of puerarin o n hemorrheology and fibrin monomer polymerization in patients with acute cerebral infarction. Methods:84 cases of acute cerebral infarction were rando mly divided into 2 equal groups, the puerarin group and the control group. Patie nts of the control group were treated with conventional measures including dehyd ration, brain protection, amelioration of microcirculation ect.. On the basis of these measures, patients of the puerarin group were given each 250 mL (600 mg) of puerarin administered by intravenous instillation q.d. for 10 consecution day s. Hemorrheology and fibrin monomer polymerization were assayed before as well a s on day 10 of the treatment. Results:The overall effectives rates in the puerarin gro up and control group were 95.23% and 76.19%, respectively(P<0.05). Hemorrhe ology and the function of fibrin monomer polymerization in patients of the puera rin group were significantly ameliorated as compared with those of the control g roup(P<0.01). Conclusion:Puerarin was shown to be effective in the tre atment of acute cerebral infarction possibly by improving hemorrheology and the function of fibrin monomer polymerization.