p53 protein accumulation as a prognostic marker in sporadic colorectal cancer |
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Authors: | Yuan-Tzu Lan Shih-Ching Chang Anna Fen-Yau Li Tzu-Chen Lin Wei-Shone Chen Jeng-Kai Jiang Shung-Haur Yang Huann-Sheng Wang Jen-Kou Lin |
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Institution: | (1) Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital & National Yang-Ming University, 201 Section 2, Shih-Pai Road, Taipei, 112, Taiwan;(2) Department of Pathology, Taipei Veterans General Hospital, National Yang-Ming University, 201 Section 2, Shih-Pai Road, Taipei, 112, Taiwan |
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Abstract: | Background and aims p53 protein plays a crucial role in the pathogenesis of a large number of malignancies. In this study, our goal was to elucidate
the prognostic role of p53 overexpression and its relationship to clinicopathological variables in colorectal cancer.
Materials and methods Between 1999 and 2004, surgical specimens of 258 patients who received surgical treatment for colorectal cancer at the Veterans
General Hospital, Taipei were collected. p53 expression in tumor tissue was evaluated by immunohistochemical analysis using
the human p53-specific mouse monoclonal antibody, PAb 1801.
Results Of the 258 patients, 97 (37.6%) had overexpression of p53 in tumor tissues. The accumulation of p53 protein in tumor tissues
did not correlate with age, gender, preoperative serum carcinoembryonic antigen (CEA) level, mucin content, nodal status,
and tumor stage. A statistically significant correlation was found between p53 overexpression and location of the tumor in
the rectum (p=0.038). Well to moderately differentiated tumors had significantly higher frequency of p53 overexpression than poorly differentiated
tumors (40.0 vs 20.0%, p=0.050). Each patient was followed up for a minimum of 2 years (median 35 months). In univariate analysis, 3-year cancer-specific
survival rate was significantly higher in patients with tumor p53 overexpression (88.2%) than in patients without overexpression
(log rank test, p=0.037). However, in multivariate analysis, the tumour node metastasis stage remained the most significant independent prognostic
factor.
Conclusion The accumulation of p53 protein might have a favorable prognostic value in colorectal cancer, but it is not an independent
prognostic factor. |
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Keywords: | Colon Rectum Carcinoma p53 protein Prognosis |
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