肝功能异常与代谢综合征的关系

目的研究肝功能异常与代谢综合征的关系。方法在体检人群中选择乙型肝炎表面抗原和丙型肝炎抗体阴性的3500例受检者,分别测量身高、体重、血压,检测血脂、血糖等生化指标。血清丙氨酸转氨酶〉50U/L视为肝功能异常。结果肝功能异常检出率为8.74%。超重或肥胖、高血压、高甘油三酯、高血糖和代谢综合征的患病率分别为34.97%,19.09%,35.37%,10.03%和10.09%,肝功能异常组各指标患病率均高于肝功能正常组（P〈0.05）。调整年龄和性别变量后的多因素回归分析提示,肝功能异常组患代谢综合征的危险性是肝功能正常组的3.927倍,95%CI为2.885～5.319。结论代谢综合征的主要构成组分（超重或肥胖、高甘油三酯、高血糖和高血压）与肝功能异常相关。

Association between Abnormal Liver Function and Risk Factors for Metabolic Syndrome

Objective To study the association between abnormal liver function and risk factors for metabolic syndrome in residents of Zhejiang province. Methods A total of 3500 subjects who were negative for HBsAg and HBcAb and took health examination in our sanatorium, was selected. Body height, body weight, blood pressure, biochemistry items including alanine aminortransferase, fasting blood glucose, high-density lipoprotein cholesterol, triglycerides were detected. Subjects with elavated serum alanine aminotransferase （〉50U/L） were considered to have abnormal liver function. Results The prevalence of abnormal liver function was 8.74%. The prevalence of overweight, hypertension, high triglycerides, high serum glucose and metabolic syndrome was 34.97%, 19.09%, 35.37%, 10.03% and 10.09%, respectively. The prevalent rates of items above were significantly higher in subjects with with abnormal liver function than in subjects with normal liver function （all P〈0.05）. The results of multivariate logistic regression analysis after adjusted by age and gender showed that the OR value for metabolic syndrome in subjects with abnormal liver function was as 3.927 times as in normal subjects （95%CI： 2.885N5.319）. Conclusion Body mass index, triglyceride level, glucose and blood pressure were the main risk factors for metabolic syndrome associated with abnormal liver function in Zhejiang province.