5-HT at hypoglossal motor nucleus and respiratory control of genioglossus muscle in anesthetized rats |
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Authors: | Sood Sandeep Liu Xia Liu Hattie Nolan Philip Horner Richard L |
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Affiliation: | Department of Medicine, University of Toronto, Room 6368, Medical Sciences Building, 1 Kings College Circle, Toronto, Ont., Canada M5S 1A8. |
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Abstract: | Serotonin (5-HT) from medullary raphe neurons excites hypoglossal motoneurons innervating genioglossus (GG) muscle. Since some raphe neurons also show increased activity in hypercapnia, we tested the hypothesis that serotonergic mechanisms at the hypoglossal motor nucleus (HMN) modulate GG activity and responses to CO2. Seventeen urethane-anesthetized, tracheotomized and vagotomized rats were studied. Microdialysis probes were used to deliver mianserin (5-HT receptor antagonist, 0 and 0.1 mM) or 5-HT (eight doses, 0-50 mM) to the HMN during room air or CO2-stimulated breathing. Mianserin decreased respiratory-related GG activity during room air and CO2-stimulated breathing (P<0.001), and also suppressed GG responses to CO2 (P=0.05). In contrast, GG activity was increased by 5-HT at the HMN, and was further increased in hypercapnia (P<0.02). However, 5-HT increased respiratory-related GG activity at levels lower (1 mM) than those eliciting tonic GG activity (10-30 mM 5-HT). The results show that 5-HT at the HMN contributes to the respiratory control of GG muscle. |
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Keywords: | Carbon dioxide, genioglossus activity Control of breathing, CO2 response Disease, obstructive sleep apnea Mammals, rat Nucleus, hypoglossal motor |
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