| Implication of EMT Induced by TGF-β1 in Pancreatic Cancer |
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| 引用本文： | 殷涛,王春友,刘涛,赵刚,周峰.Implication of EMT Induced by TGF-β1 in Pancreatic Cancer[J].华中科技大学学报(医学英德文版),2006,26(6):700-702. |
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| 作者姓名： | 殷涛 王春友 刘涛 赵刚 周峰 |
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| 作者单位： | Pancreatic Center, Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| 基金项目： | This project was supported by a grant from the National Natural Sciences Foundation of China （No. 30571817）. |
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| 摘 要： | This study examined the implication of EMT induced by TGF-β1 in pancreatic cancer invasion. TGF-β1 expression was determined in 29 cases of human pancreatic carcinoma （PC） by immunohistochemistry and the results were compared with those of pathological examination. Moreover, the effects of TGF-β1 on the phenotype and invasion of pancreatic cancer cell line Panc-1 were also investigated. TGF-β1 was detected in 12 cases （41.4 %） of PC. Significant correlation was found between the expression of TGF-β1 and lymph node involvement （P=0.047） and the depth of invasion （P=0.035）. TGF-β1 obviously promoted EMT of Panc-1 cell lines and their invasion ability was substantially enhanced. TGF-β1 may promote the malignancy of pancreatic cancer by triggering EMT.
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| 关 键 词： | 胰腺癌 淋巴 肿瘤细胞 治疗 |
| 收稿时间： | 2006-09-20 |
| 修稿时间： | 2006-09-20 |
Implication of EMT induced by TGF-β1 in pancreatic cancer |
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| Tao Yin,Chunyou Wang,Tao Liu,Gang Zhao,Feng Zhou.Implication of EMT induced by TGF-β1 in pancreatic cancer[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(6):700-702. |
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| Authors: | Tao Yin Chunyou Wang Tao Liu Gang Zhao Feng Zhou |
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| Institution: | (1) Pancreatic Center, Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China |
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| Abstract: | Summary This study examined the implication of EMT induced by TGF-β1 in pancreatic cancer invasion. TGF-β1 expression was determined
in 29 cases of human pancreatic carcinoma (PC) by immunohistochemistry and the results were compared with those of pathological
examination. Moreover, the effects of TGF-β1 on the phenotype and invasion of pancreatic cancer cell line Panc-1 were also
investigated. TGF-β1 was detected in 12 cases (41.4 %) of PC. Significant correlation was found between the expression of
TGF-β1 and lymph node involvement (P=0.047) and the depth of invasion (P=0.035). TGF-β1 obviously promoted EMT of Panc-1 cell lines and their invasion ability was substantially enhanced. TGF-β1
may promote the malignancy of pancreatic cancer by triggering EMT.
This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30571817). |
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| Keywords: | pancreatic cancer TGF-β 1 EMT |
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