LH-RH in picomole concentrations evokes excitation and inhibition of rat arcuate neurones in vitro |
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Authors: | A E Herbison J I Hubbard N E Sirett |
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Affiliation: | Department of Physiology, University of Otago School of Medicine, P.O. Box 913, Dunedin New Zealand |
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Abstract: | A medial sagittal brain slice was developed, which enabled electrophysiological recording from spontaneously active neurones adjacent to the infundibular recess of the rat arcuate nucleus. Luteinizing hormone-releasing hormone (LH-RH) (10 nM-10 pM) significantly altered the frequency of 21 out of 31 units tested, exciting 14 and inhibiting 7 others. The excitatory responses were often not maintained during the exposure to LH-RH but either returned to pre-exposure frequency or displayed an inhibition of discharge. A neural model incorporating recurrent inhibition of LH-RH-excited neurones is proposed to explain these responses, thought to be endogenously evoked by collateral innervation of the arcuate nucleus by medial preoptic neurones projecting to the median eminence. |
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Keywords: | LH-RH recurrent inhibition arcuate nucleus brain slice |
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