| 抗呆合剂对小鼠缺血再灌注脑内氨基酸、乙酰胆碱酯酶活力的影响 |
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| 引用本文： | 唐一鹏,赵树民,孙丽萍,胡京红,贾绪东,洪庆涛. 抗呆合剂对小鼠缺血再灌注脑内氨基酸、乙酰胆碱酯酶活力的影响[J]. 北京中医药大学学报, 1999, 22(4): 2 |
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| 作者姓名： | 唐一鹏 赵树民 孙丽萍 胡京红 贾绪东 洪庆涛 |
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| 作者单位： | 北京中医药大学中西医结合研究所,北京100029 |
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| 摘 要： | 反复脑缺血再灌注后５０ｍｉｎ，小鼠脑内谷氨酸（Ｇｌｕ）、天冬氨酸（Ａｓｐ）均升高，γ－氨基丁酸（ＧＡＢＡ），也随之升高。抗呆合剂大、小剂量均可抑制Ｇｌｕ、Ａｓｐ的升高，大剂量还使升高的ＧＡＢＡ恢复至接近正常。造模后５０ｍｉｎ以及７ｄ，模型组小鼠乙酰胆碱酯酶（ＡｃｈＥ）活力降低，抗呆合剂可升高ＡｃｈＥ活力。
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| 关 键 词： | 脑缺血再灌 抗呆合剂 谷氨酸 乙酰胆碱酯酶 小鼠 |
| 修稿时间： | 1998-11-24 |
Effects of KangDaiHeJion Intracerebral Amino Acid and AchE Activity of Ischemia Reperfusion Mouse |
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| Tang Yipeng. Effects of KangDaiHeJion Intracerebral Amino Acid and AchE Activity of Ischemia Reperfusion Mouse[J]. Journal of Beijing University of Traditional Chinese Medicine, 1999, 22(4): 2 |
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| Authors: | Tang Yipeng |
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| Abstract: | After repeated cerebral ischemia and reperfusion, 50 minutes later, the mouse intracerebral glutamic acid (Glu) and asparaginic acid (Asp) level increased, then the level of gamma aminobutyric acid (GABA) increased as well. Both large and small dose of Kangdaiheji (KDHJ) can inhibit the increase of Glu and Asp. A large dose of KDHJ can lower the GABA near to normal level. In 50 minutes to 7 days after creating the mouse model of which the acetylcholinesterase (AchE) activity was inhibited, KDHJ improved the AchE activity. |
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| Keywords: | Cerebral ischemia reperfusion Kangdaiheji Glu AchE Mouse |
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