Whole blood and mononuclear cell glutathione response to dietary whey protein supplementation in sedentary and trained male human subjects |
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Authors: | N Middleton P Jelen G Bell |
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Institution: | 1. Faculty of Agriculture, Food and Nutritional Sciences, Edmonton, Alberta, Canada, T6G 2E2paul.jelen@ualberta.ca;3. Faculty of Agriculture, Food and Nutritional Sciences, Edmonton, Alberta, Canada, T6G 2E2;4. Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada, T6G 2E2 |
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Abstract: | Sedentary male subjects (n=9) on a controlled diet were fed two doses (0.8 or 1.6 g/kg body mass) of a whey protein isolate (WPI), in addition to an isocaloric placebo; blood samples were drawn over a 4-h period and glutathione concentration determined. There was no effect of the supplementation at either level over the 4-h sampling period. The effects of a WPI supplemented diet on glutathione concentrations in whole blood as well as peripheral mononuclear cell populations were also investigated over a 6-week period in male subjects (n=18) involved in arduous aerobic training; blood was collected prior to and following a 40 km simulated cycling trial. The aerobic training period resulted in significantly lower glutathione concentrations in whole blood, an effect that was mitigated by WPI supplementation. A significant increase in mononuclear cell glutathione was also observed in subjects receiving the WPI supplement following the 40 km simulated cycling trial. |
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Keywords: | sunflower oil groundnut oil linoleic acid insulin resistance Asian Indians |
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