Quercetin is bioavailable from a single ingestion of grape juice |
| |
Authors: | Alberto Dávalos Patricia Castilla Carmen Gómez-Cordovés |
| |
Affiliation: | 1. Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain;2. Instituto de Fermentaciones Industriales, CSIC, Madrid, Spain |
| |
Abstract: | The in vivo bioactivity of polyphenols will depend on their bioavailability. Grape juice is an important source of dietary phenolics. This paper reports results that prove that quercetin (3,3′,4′,5,7-pentahydroxyflavone) is bioavailable after a single ingestion of red grape juice by healthy volunteers. Blood plasma samples were collected before and after 2 h of ingestion of 100 ml of concentrated grape juice (n = 14), and of a placebo solution (n =6). Significant differences in the variation of the total plasma quercetin content (before and after ingestion) between the grape juice ingestion group (3.1 µg/l increase, as a mean) and the placebo group (6.0 µg/l decrease, as a mean) were found. This relatively low increase in comparison with that obtained after 2 h of ingestion of onions (201 µg/l, as a mean) and with those reported in the literature for other foods/beverages was attributed to differences in the amount of quercetin ingested, in the form in which quercetin is present, and in the food matrix. |
| |
Keywords: | Red grape juice quercetin plasma bioavailability |
|
|