慢性非传染性疾病对老年与非老年急性脑梗死患者发生多器官功能不全综合征的影响对照研究

目的分析慢性非传染性疾病对急性脑梗死患者发生多器官功能不全综合征（MODS）的影响。方法将864例急性脑梗死患者分为两组：老年组（n=594）[平均年龄（71．39±6．70）岁（60-94岁）]，和非老年组（n=270）[年龄（49．58±8．34）岁（18-59岁）]。老年组发生MODS154例（25．9％），非老年组发生MODS39例（14．4％）。将可能对急性脑梗死患者MODS的发生产生影响的慢性非传染性疾病进行多因素Logistic回归分析，寻找其中的危险因素。结果在老年组，慢性非传染性疾病中糖尿病、高血压、心血管慢性病、呼吸系统慢性病、肾脏慢性病是急性脑梗死患者多器官功能不全综合征发生的主要危险因素；在非老年组，高血压、心血管慢性病是主要危险因素。结论老年组的慢性基础病和多器官功能衰竭的发生率高于非老年组。不同年龄组的脑梗死患者发生MODS的主要危险因素不完全相同。

Influence of chronic non-infectious disease on the occurrence of multiple organ dysfunction syndrome induced by acute cerebral infarction in elderly and non-elderly patients

Objective To study the influences of chronic non-infectious diseases on the occurrence of multiple organ dysfunction syndrome （MODS） induced by acute cerebral infarction （ACI） in patients of different ages. Methods 864 patients with ACI were divided into two groups according to the age： elderly group （n=594）, aged （71.39±6.70） （60-94）, and non-elderly group （n=270）, aged （49.58±8.34） （18-59）. There were 154 cases of MODS in the elderly group with an incidence rate of 25.9%, significantly higher than that in the non-elderly group （39/270, 14.4%, P〈0.05）. Multivariate Logistic regression was used to analyze the potential risk factors of ACI-induced MODS in these 2 groups. Results Diabetes, hypertensive diseases, chronic cardiovascular diseases, chronic lung diseases, and chronic renal diseases were the principal risk factors of ACI-induced MODS in the elderly group; and hypertensive diseases and chronic cardiovascular diseases were the principal risk factors in the non-elderly group. Conclusion The prevalence rates of chronic non-infectious diseases and ACI of the elderly people are significantly higher than those of the non-elderly people. The principal risk factors of ACI-induced MODS are different in the people of different ages.