表皮生长因子受体在胸腺肿瘤中的表达及其临床意义

目的　探讨表皮生长因子受体 (EGFR)在胸腺瘤发生发展中的作用及临床意义。方法　应用免疫组化S P法检测 2 9例胸腺瘤 ,1 1例正常胸腺组织中的表皮生长因子受体 (EGFR)表达。结果　胸腺瘤EGFR阳性表达率为 75 .9% (2 2 /2 9) ,非常显著高于正常胸腺组织 1 8.2 % (2 /1 1 ) (P <0 .0 1 )。恶性胸腺瘤的阳性表达率 88.9% (1 6 /1 8)非常显著高于良性胸腺瘤 5 4.5 % (6 /1 1 ) (P <0 .0 1 )。胸腺瘤Masaoka分期Ⅲ、Ⅳ期的阳性表达率非常显著高于I期 (P <0 .0 1 )。良性胸腺瘤中无强阳性表达 ,5例强阳性表达的恶性胸腺瘤中 ,术后随访 3例发生局部复发或转移。但EGFR的表达与是否合并重症肌无力 (MG) ,组织学类型无关。结论　提示EGFR的表达与胸腺瘤的发生发展有一定关系 ,EGFR过度表达者复发和转移的危险性较高 ,应加强放疗化疗及术后随访

Expression of epidermal growth factor receptor in thymoma and its clinical significance

Objective　To study the effect of epidermal growt h factor receptor(EGFR) on the development and progress of thymoma. Me thods Expression of EGFR was detected by immunohistochemical stain in t he tissues of 11 cases of normal thymus and 29 cases of thymoma. Result s　 The positive expression of EGFR was 75.9%(22/29) in thymomas and 18.2%(2/11) in normal thymus. The difference was significant(P<0.01). The positive rate of EGFR was higher in invasive thymomas than in non-invasive ones (P<0.01). T he positive rate of EGFR increased with Masaoka stage with a significant increm ent in Ⅲ-Ⅳ stage compared with I stage (P<0.01). EGFR was strongly expre ssed in 5 cases of invasive thymomas, in which recurrence or metastasis occurred in 3 during the follow-up period after operation. But there was no statistical correlation with whether complicated with myasthenia gravis (MG) and histolog ical type. Conclusion　EGFR might be related to the tumori genesis and development of thymoma. There is high risk of recurrence and metast asis in case of EGFR over-expression and radiotherapy, chemotherapy and follow up should be enhanced.