| 脂联素基因多态性与冠心病研究进展 |
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| 引用本文： | 贾爱梅,陈开,宋永砚. 脂联素基因多态性与冠心病研究进展[J]. 中国动脉硬化杂志, 2020, 28(7): 627-633 |
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| 作者姓名： | 贾爱梅 陈开 宋永砚 |
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| 作者单位： | 川北医学院附属医院血管外科;川北医学院基础医学院 代谢病药物与生物制品南充市重点实验室,四川省南充市 637000 |
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| 基金项目： | 四川省教育厅重点项目(17ZA0172);南充市校合作科研专项(NSMC20170403) |
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| 摘 要： | 脂联素(APN)是脂肪组织分泌的具有心血管保护活性的多肽,其基因呈现多态性,位于启动子区(rs266729)、外显子区(rs2241766)和内含子区(rs1501299)的三个多态性位点被广泛报道与冠心病(CHD)显著相关,其他位点如rs12495941、rs822395、rs182052、rs3774261和rs17366568也有报道与CHD显著相关。在关联机制上,APN基因多态性主要通过降低血浆APN水平、引起血脂紊乱、升高血压和促进肥胖等机制而增加CHD风险。文章就APN基因多态性与CHD的相关性及关联机制作一综述。
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| 关 键 词： | 脂联素 基因多态性 冠心病 血压 血脂 |
| 收稿时间： | 2019-07-01 |
| 修稿时间： | 2019-10-28 |
Research progress of association between adiponectin gene polymorphism and coronary heart disease |
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| JIA Aimei,CHEN Kai,SONG Yongyan. Research progress of association between adiponectin gene polymorphism and coronary heart disease[J]. Chinese Journal of Arteriosclerosis, 2020, 28(7): 627-633 |
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| Authors: | JIA Aimei CHEN Kai SONG Yongyan |
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| Abstract: | Adiponectin (APN) is a cardioprotective polypeptide secreted by adipose tissue. Its gene is polymorphic. Three polymorphic loci, located in promoter region (rs266729), exon region (rs2241766) and intron region (rs1501299) respectively, are widely reported to be significantly associated with coronary heart disease (CHD). Other polymorphisms such as rs12495941, rs822395, rs182052, rs3774261 and rs17366568 were also reported to be significantly associated with CHD. In mechanisms, the polymorphisms of APN gene increased the risk of CHD mainly by reducing plasma APN level, causing lipid disorders, elevating blood pressure and promoting obesity. This article reviews the relationship between the polymorphisms of APN gene and CHD, as well as the underlying mechanisms. |
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| Keywords: | adiponectin polymorphism coronary heart disease blood pressure blood lipid |
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