麝香保心丸联合瑞舒伐他汀治疗对老年冠心病患者血脂、血管内皮功能及外周血microRNA-126和microRNA-137表达的影响

目的探讨麝香保心丸联合瑞舒伐他汀治疗对老年冠心病患者血脂、血管内皮功能及外周血microRNA-126和microRNA-137表达的影响。方法采用随机数字表法将收治的94例老年冠心病患者分为对照组(47例)与麝香保心丸联合组(47例)。对照组患者给予瑞舒伐他汀治疗;麝香保心丸联合组患者在给予瑞舒伐他汀治疗基础上结合麝香保心丸治疗。两组疗程均为12周。比较两组治疗疗效及治疗前后血脂、血管内皮功能麝香保心丸联合组总有效率(93. 62%)高于对照组(70. 21%,P0. 05)。两组治疗后总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)和甘油三酯(TG)水平较治疗前降低,而高密度脂蛋白胆固醇(HDLC)水平较治疗前升高(P0. 05);麝香保心丸联合组治疗后TC、LDLC和TG水平低于对照组,而HDLC水平高于对照组(P0. 05)。两组治疗后内皮素1(ET-1)水平较治疗前降低,而一氧化氮(NO)水平较治疗前升高(P0. 05);麝香保心丸联合组治疗后ET-1水平低于对照组,而NO水平高于对照组(P0. 05)。两组治疗后microRNA-126表达较治疗前升高,而microRNA-137表达较治疗前降低(P0. 05);麝香保心丸联合组治疗后microRNA-126表达高于对照组,而microRNA-137表达低于对照组(P0. 05)。结论麝香保心丸联合瑞舒伐他汀治疗对老年冠心病患者疗效良好,可改善患者血脂代谢紊乱和血管内皮功能紊乱,上调外周血microRNA-126表达而下调microRNA-137表达,值得临床借鉴。

Effects of Musk Baoxin pill combined with rosuvastatin on serum lipid,vascular endothelial function and expression of microRNA-126 and microRNA-137 in peripheral blood of elderly patients with coronary heart disease

Aim To investigate the effects of Musk Baoxin pill combined with rosuvastatin on blood lipid, vascular endothelial function and expression of microRNA-126 and microRNA-137 in peripheral blood of elderly patients with coronary heart disease. Methods The 94 elderly patients with coronary heart disease were divided into control group (47 cases) and observation group (47 cases) by random number table method. The patients in control group were treated with rosuvastatin, while the patients in observation group were treated with Musk Baoxin pill on the basis of control group.Both groups were treated for 12 weeks. The therapeutic effect, blood lipid, vascular endothelial function and expression of microRNA-126 and microRNA-137 in peripheral blood were compared between two groups before and after treatment. Results The total effective rate of observation group (93.62%) was higher than that of control group (70.21%, P<0.05). After treatment, total cholesterol (TC), low-density lipoprotein cholesterol (LDLC) and triglyceride (TG) levels were lower in two groups than those before treatment, while high-density lipoprotein cholesterol (HDLC) levels were higher than those before treatment (P<0.05); after treatment, TC, LDLC and TG levels in observation group were lower than those in control group, while HDLC levels were higher than those in control group (P<0.05). After treatment, endothelin-1 (ET-1) level in two groups was lower than that before treatment, while nitric oxide (NO) level was higher than that before treatment (P<0.05); after treatment, ET-1 level in observation group was lower than that in control group, while NO level was higher than that in control group (P<0.05). After treatment, the expression of microRNA-126 increased and microRNA-137 decreased in both groups (P<0.05); after treatment, the expression of microRNA-126 in observation group was higher than that in control group, while the expression of microRNA-137 was lower than that in control group (P<0.05). Conclusions Musk Baoxin pill combined with rosuvastatin has a good effect on elderly patients with coronary heart disease. It can improve blood lipid metabolism disorder and vascular endothelial dysfunction, and up-regulate microRNA-126 expression in peripheral blood and down-regulate microRNA-137 expression, which is worthy of clinical reference.