| 基于Box-Behnken响应面优化的当归挥发油胶体磨包合工艺 |
| |
| 引用本文： | 高艳红,刘仁涛,武光云,张琳春,关永霞. 基于Box-Behnken响应面优化的当归挥发油胶体磨包合工艺[J]. 现代中药研究与实践, 2020, 34(2): 49-53. DOI: 10.13728/j.1673-6427.2020.02.010 |
| |
| 作者姓名： | 高艳红 刘仁涛 武光云 张琳春 关永霞 |
| |
| 作者单位： | 鲁南制药集团股份有限公司,山东临沂276006;中药制药共性技术国家重点实验室,山东临沂276006;鲁南制药集团股份有限公司,山东临沂276006 |
| |
| 摘 要： | 目的优化当归挥发油胶体磨研磨包合的工艺条件。方法以当归挥发油的包封率和包合物收率及综合评分为指标,在单因素基础上,采用Box-Behnken响应面法进行优化,确定了当归挥发油胶体磨研磨包合的最佳工艺条件。结果最佳包合工艺条件为:挥发油(ml)与β-CD(g)的比例为1∶10,β-CD(g)与水(ml)的比例为1∶3,研磨包合时间为19 min。结论优选的当归挥发油胶体磨包合工艺操作简便,包合率高,包合效果好,可用于大规模工业化生产。
|
| 关 键 词： | 当归 挥发油 响应面分析 胶体磨包合 |
Optimization of Colloid Mill Inclusion Process of Angelica sinensis(Oliv.)Diels Volatile Oil Based on Box-Behnken Method |
| |
| GAO Yan-hong,LIU Ren-tao,WU Guang-yun,ZHANG Lin-chun,GUAN Yong-xia. Optimization of Colloid Mill Inclusion Process of Angelica sinensis(Oliv.)Diels Volatile Oil Based on Box-Behnken Method[J]. Research and Practice on Chinese Medicines, 2020, 34(2): 49-53. DOI: 10.13728/j.1673-6427.2020.02.010 |
| |
| Authors: | GAO Yan-hong LIU Ren-tao WU Guang-yun ZHANG Lin-chun GUAN Yong-xia |
| |
| Affiliation: | (Lunan Pharmaceutical Group Co.Ltd.,Linyi 276006,China;State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine(TCM),Linyi 276006,China) |
| |
| Abstract: | Objective To confirm the optimum technological conditions of colloid mill inclusion process of Angelica sinensis(Oliv.)Diels volatile oil.Methods On the basis of single factor test,Box-Behnken is used to optimize the optimum technological conditions of Colloid mill inclusion process of Angelica sinensis(Oliv.)Diels volatile oil,with yield of inclusion compound,inclusion rate of volatile oil-β-CD and comprehensive score as evaluation indexes.Results The optimum technological conditions are β-CD-volatile oil ratio is 1:10,β-CDpure water ratio is 1:3,and the inclusion time is 19 min.Conclusion This optimal echnological conditions of colloid mill inclusion process of Angelica sinensis(Oliv.)Diels volatile oil is simple operation,high inclusion rate and good inclusion effect,which can be used in industrial production. |
| |
| Keywords: | Angelica sinensis(Oliv.)Diels volatile oil response surface methodology colloid grinding inclusion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
