| 自噬在天然药物活性成分抗心血管衰老中的作用 |
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| 引用本文： | 易欧阳,台适,卜兰兰,周磊,郑熙隆.自噬在天然药物活性成分抗心血管衰老中的作用[J].中国动脉硬化杂志,2020,28(2):175-180. |
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| 作者姓名： | 易欧阳 台适 卜兰兰 周磊 郑熙隆 |
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| 作者单位： | 湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室,湖南省长沙市 410208,中南大学湘雅二医院,湖南省长沙市 410011,湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室,湖南省长沙市 410208,湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室,湖南省长沙市 410208,湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室,湖南省长沙市 410208 |
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| 基金项目： | 国家自然科学基金项目(81773736)；湖南中医药大学研究生创新课题项目(2018CX02) |
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| 摘 要： | 心血管系统维持着机体正常的生命活动,心血管系统衰老可引发高血压、动脉粥样硬化、心力衰竭、心肌梗死等疾病。自噬是一种溶酶体依赖性降解途径,其水平随着年龄增加而逐渐降低,一方面提高机体自噬可延缓细胞和组织衰老,另一方面自噬水平的过度激活可诱导细胞自噬性死亡、加速衰老。某些天然药物活性成分能调节自噬,并改善心血管系统衰老。它们可能是通过调节细胞自噬发挥对心血管系统衰老的保护作用。因此,文章就自噬在天然药物活性成分延缓心血管系统衰老中的作用及研究进展进行综述。
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| 关 键 词： | 衰老 心血管系统 自噬 天然药物活性成分 |
| 收稿时间： | 2019/5/3 0:00:00 |
| 修稿时间： | 2019/7/20 0:00:00 |
The roles of autophagy and its research progress in the prevention of cardiovascular aging by natural pharmaceutical active ingredients |
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| YI Ouyang,TAI Shi,BU Lanlan,ZHOU Lei and ZHENG Xilong.The roles of autophagy and its research progress in the prevention of cardiovascular aging by natural pharmaceutical active ingredients[J].Chinese Journal of Arteriosclerosis,2020,28(2):175-180. |
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| Authors: | YI Ouyang TAI Shi BU Lanlan ZHOU Lei and ZHENG Xilong |
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| Institution: | Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208,China,The Second Xiangya Hospital of Central South University, Changsha,Hunan 410011, China,Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208,China,Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208,China and Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208,China |
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| Abstract: | The cardiovascular system maintains normal life activities of the body, and the cardiovascular system aging will cause diseases such as hypertension, atherosclerosis, heart failure, myocardial infarction. Autophagy is a lysosomal-dependent degradation pathway. The level of autophagy gradually decreases with age. On one hand increasing autophagy can delay cells and tissues aging. On the other hand, excessive activation of autophagy levels will induce autophagic death and accelerate aging. Some natural pharmaceutical active ingredients regulate autophagy and ameliorate cardiovascular system aging. They may play a protective role in the aging of the cardiovascular system by regulating cellular autophagy. Therefore, this article reviews the role of autophagy and its research progress in the prevention of cardiovascular aging in natural pharmaceutical active ingredients. |
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| Keywords: | aging cardiovascular system autophagy natural pharmaceutical active ingredients |
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