当归四逆汤加减治疗白血病微小残留病的临床观察

目的 回顾性分析当归四逆汤加减治疗急性白血病(AL)患者微小残留病(MRD)的情况.方法 以2013年1月至2019年1月就诊于中国中医科学院西苑医院血液科门诊的60例AL患者作为研究对象;采用病例系列研究的方法,根据患者提供的病历资料,AML患者MRD≥10-3为阳性,ALL患者MRD≥10-4为阳性;观察当归四逆汤...

Use of modified Dangguisini Decoction for treatment of minimal residual disease in leukemic patients: a clinical study

Objective To investigate the value of modified Dangguisini Decoction in the treatment of minimal residual disease(MRD)in patients with acute leukemia(AL).Methods Included in this study were 60 AL patients registered to the Clinic of Hematology,Xiyuan Hospital of China Academy of Chinese Traditional Medical Sciences between January 2013 and January 2019.According to the medical records in this case series,MRD positivity was considered when leukemic cells were greater than or equal to 10-3 for patients with acute myeloid leukemia(AML),or greater than or equal to 10-4 for patients with acute lymphoblastic leukemia(ALL).Before and at 6 months after treatment with modified Dangguisini Decoction,the MRD,white blood cell(WBC)counts,hemoglobin(Hb),and platelet(PLT)were examined in all AL patients.Results There were 31 MRD-positive AL patients before treatment,18 of whom(58%)turned MRD-negative after 6 months of treatment with Dangguisini Decoction.There were 29 MRD-negative AL patients before treatment;only 3 became MRD-positive after 6 months of treatment with Dangguisini Decoction.Compared with before treatment,WBC and Hb levels were significantly higher in patients after treatment with modified Dangguisini Decoction,with statistically significant differences(P<0.05).There was no significant change in PLT level before and after treatment(P>0.05).Conclusion Treatment of AL with modified Dangguisini Decoction may help maintain MRD negativity,and also lead to negative conversion in part of MRD-positive patients.