The prognostic value and clinical utility of estrogen and progesterone receptors in endometrial carcinoma |
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| Affiliation: | 1. Department of Sport, School of Physical Education and Sport, University of São Paulo, São Paulo, SP, Brazil;2. Graduate Program in Collective Health, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil;3. Center of Mathematics, Computation, and Cognition, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil;4. Department of Biomedical Engineering, The City College of New York of CUNY, New York, NY, United States;5. Research Institute of Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom;6. Santos Dumont Institute (Instituto Internacional de Neurociências Edmond e Lily Safra), Natal, Rio Grande do Norte, Brazil;7. Sport Science Program (PPGCEE), State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil;8. Red Bull Brazil, São Paulo, Brazil;9. Brazilian Institute of Neuroscience and Neurotechnology. Research, Innovation and Dissemination Centers - The São Paulo Research Foundation (BRAINN/CEPID-FAPESP), University of Campinas, Campinas, Brazil;1. Heilbrunn Department of Population & Family Health, Columbia University Mailman School of Public Health, New York;2. Department of Epidemiology, Columbia University Mailman School of Public Health, New York;3. Columbia University Irving Medical Center, Augustus C. Long Health Sciences Library, New York;4. Columbia University Irving Medical Center, Department of Pediatrics, Division of Child and Adolescent Health, New York;5. NewYork-Presbyterian, School-Based Health Centers, New York;1. Capital University of Physical Education and Sports, Beijing 100191, China;2. Department of Pharmacology, the University of Tennessee College of Medicine Memphis, Tennessee 38163, United States;3. Renmin University of China, Beijing 100872, China;4. Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, United States;1. Physical Performance & Sports Research Center, Universidad Pablo de Olavide, Seville, Spain;2. Department of Sport and Informatics, Universidad Pablo de Olavide, Seville, Spain;3. Human Performance and Sport Science Laboratory, University of Murcia, Murcia, Spain;1. Department of Physical Education, Federal University of Piaui, Teresina, PI, Brazil;2. School of Veterinary Medicine, Federal University of Vale do São Francisco, Petrolina, PE, Brazil;3. Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil;4. School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil;5. Department of Biophisics, Palista School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil |
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| Abstract: | In the United States, endometrial carcinoma is the most common gynecologic malignancy, and accounts for 4,900 deaths per year in the United States. While this disease has relatively good cure rates, there is motivation to describe other determinants, which may help in the treatment of this disease. Attempts have been made to correlate hormone receptor status with disease-free intervals and survival in patients with endometrial carcinoma. The weight of evidence seems to support that of the two hormone receptors, progesterone is the more significant predictor of patient outcome. If hormone receptors are to be used in the management of endometrial carcinoma, they should be determined by immunohistochemistry. In the adjuvant setting, patients with progesterone positive tumors are more amenable to treatment with progestational agents than are patients with receptor negative tumors. Future areas of research include the use of tamoxifen and selective estrogen receptor modulators in the chemoprevention and treatment of endometrial carcinoma. |
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